Citations 2
Cross‐sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle‐aged individuals with a parental history of either autosomal dominant or late‐onset Alzheimer's disease
Xiong, Chengjie , McCue, Lena , Buckles, Virginia, Grant, Elizabeth, Agboola, Folasade, Coble, Dean W. , Bateman, Randall J. , Fagan, Anne M. , Hassenstab, Jason , Moulder, Krista L., Gordon, Brian A. , Day, Gregory S. , Suzuki, Kazushi , Vöglein, Jonathan , Morris, John C. , (DIAN), and Dominantly Inherited Alzheimer Network, Gordon, Brian A , Day, Gregory S , Bateman, Randall J , Vöglein, Jonathan , Xiong, Chengjie , Hassenstab, Jason , Morris, John C , Xiong, Chengjie , Benzinger, Tammie L.S. , Schindler, Suzanne E. , McDade, Eric , Cruchaga, Carlos , Ikeuchi, Takeshi , Allegri, Ricardo , (DIAN), and Dominantly Inherited Alzheimer Network
Alzheimer's & Dementia | January 14, 2023 | Volume: 19 | Issue: 7 | Pages: 2923-2932
AbstractBackgroundComparisons of late‐onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age.MethodsWe compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and amyloid imaging with Pittsburgh Compound‐B (PiB) across four groups of 387 cognitively normal participants, 42 to 65 years of age, in the Dominantly Inherited Alzheimer Network (DIAN) and the Adult Children Study (ACS) of LOAD: DIAN mutation carriers (MCs) and non‐carriers (NON‐MCs), and ACS participants with a positive (FH+) and negative (FH–) family history of LOAD.ResultsAt baseline, MCs had the lowest age‐adjusted level of CSF Aβ42 and the highest levels of total and phosphorylated tau‐181, and PiB uptake. Longitudinally, MC had similar increase in PiB uptake to FH+, but drastically faster decline in hippocampal volume than others, and was the only group showing cognitive decline.DiscussionPreclinical ADAD and LOAD share many biomarker signatures, but cross‐sectional and longitudinal differences may exist.
Different rates of cognitive decline in autosomal dominant and late‐onset Alzheimer disease
Buckles, Virginia, Xiong, Chengjie , Bateman, Randall J. , Hassenstab, Jason , Berman, Sarah , Chhatwal, Jasmeer P. , Fagan, Anne M. , Goate, Alison , Graff‐Radford, Neill R. , Marcus, Daniel S., Masters, Colin L. , McCue, Lena , Mori, Hiroshi , Moulder, Krista L., Noble, James M. , Paumier, Katrina L. , Preische, Oliver, Ringman, John M. , Fox, Nick C. , Salloway, Stephen , Vöglein, Jonathan , Morris, John C. , Network, for the Dominantly Inherited Alzheimer's, Bateman, Randall J , Masters, Colin L , Vöglein, Jonathan , Xiong, Chengjie , Fox, Nick C , Hassenstab, Jason , Morris, John C , Goate, Alison M , Berman, Sarah , Xiong, Chengjie , Allegri, Ricardo , Danek, Adrian , Ghetti, Bernardino , Jucker, Mathias , McDade, Eric , Schofield, Peter R. , Martins, Ralph N. , Network, for the Dominantly Inherited Alzheimer's, Noble, James M
Alzheimer's & Dementia | December 2, 2021 | Volume: 18 | Issue: 10 | Pages: 1754-1764
AbstractAs prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and “sporadic” late‐onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy‐confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy‐confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.