Citations 1
Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray
Camerini, David , Randall, Arlo, Trappl-Kimmons, Krista, Oberai, Amit , Hung, Christopher, Edgar, Joshua , Shandling, Adam D., Huynh, Vu, Teng, Andy , Hermanson, Gary, Pablo, Jozelyn , Stumpf, Megan M. , Lester, Sandra , Harcourt, Jennifer L. , Tamin, Azaibi , Thornburg, Natalie J. , Satheshkumar, Panayampalli S. , Liang, Xiaowu, Kennedy, Richard B. , Yee, Angela , Townsend, Michael B. , Campo, Joseph J. , Kennedy, Richard , Rasheed, Mohammed
Microbiology Spectrum | October 27, 2021 | Volume: 9 | Issue: 2 | Pages: No page available
With novel mutant SARS-CoV-2 variants of concern on the rise, knowledge of immune specificities against SARS-CoV-2 proteins is increasingly important for understanding the impact of structural changes in antibody-reactive protein epitopes on naturally acquired and vaccine-induced immunity, as well as broader topics of cross-reactivity and viral evolution. A multi-coronavirus protein microarray used to map the binding of COVID-19 patient antibodies to SARS-CoV-2 proteins and protein fragments as well as to the proteins of four other coronaviruses that infect humans has shown specific regions of SARS-CoV-2 proteins that are highly reactive with patient antibodies and revealed cross-reactivity of these antibodies with other human coronaviruses.