Citations 1
Analysis of flow resistance in the pulmonary arterial circulation: implications for hypoxic pulmonary vasoconstriction
Johnson, D. W. , Roy, Tuhin K. , Secomb, Timothy W. , Johnson, David W , Roy, Tuhin K , Secomb, Timothy W
Journal of Applied Physiology | August 19, 2021 | Volume: 131 | Issue: 4 | Pages: 1211-1218
10.1152/japplphysiol.00128.2021
A theoretical model of the pulmonary vasculature is used to predict the effects of vasoconstriction over specified ranges of vessel diameters on pulmonary vascular resistance (PVR). The model shows that observed levels of hypoxic vasoconstriction in terminal vessels cannot account for the elevation of PVR associated with hypoxic pulmonary vasoconstriction (HPV). Upstream signaling by conducted responses to engage constriction of arterioles, therefore, plays an essential role in the elevation of PVR during HPV.