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Engel, Jason

https://orcid.org/0000-0003-0061-374X

Mayo Clinic

University of Mississippi Medical Center

Citations 1

Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis
Chade, Alejandro , Engel, Jason , Hall, Michael E. , Eirin, Alfonso , Bidwell, Gene L. , Chade, Alejandro R , Eirin, Alfonso

American Journal of Physiology-Renal Physiology | August 16, 2021 | Volume: 321 | Issue: 4 | Pages: F411-F423

10.1152/ajprenal.00158.2021 Get It

Chronic kidney disease (CKD) is a progressive disorder with high cardiovascular morbidity and mortality. This work supports the role of inflammatory cytokines of renal origin in renal-cardio pathophysiology in CKD and that the heart may be a target. Furthermore, it supports the feasibility of a new strategy in a translational fashion, using targeted inhibition of renal NF-κB signaling to offset the development of cardiac injury in CKD.