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Yang, Sara

https://orcid.org/0000-0001-8949-1421

Mayo Clinic

Oregon Health & Science University

Citations 4

Fibula Free Flap Reconstruction of Cervical Spine Defects: A Multi‐Institutional Study
Yang, Sara , Morton, Zoey , Colcord, Maddie, Moore, Eric J. , Thuener, Jason E. , Bewley, Arnaud F. , Coughlin, Andrew, Richmon, Jeremy D. , Pipkorn, Patrik , Zender, Chad , Wax, Mark K. , Moore, Eric J , Thuener, Jason , Richmon, Jeremy D , Zender, Chad A , Wax, Mark K , Jackson, Ryan S. , Khariwala, Samir S , Winters, Ryan D. , Militsakh, Oleg N. , III, James M. Wright

The Laryngoscope | July 10, 2024 | Volume: 134 | Issue: 12 | Pages: 4923-4928

10.1002/lary.31625 Get It

IntroductionCervical spine defects result in spinal instability, putting the spinal cord and vertebral arteries at risk of damage and possibly devastating neurological injuries. The fibula free flap can span the spinal defects for stability. There is a paucity of literature on this technique.MethodMulti‐institutional retrospective case series reviewing patients who underwent cervical spine reconstruction with a fibula free flap. Patient demographic information, comorbidities, characteristics of cervical spine defects, and free flap complications were collected.ResultsA total of 1187 fibula free flaps across 10 different institutions were reviewed. Thirteen patients (1.09%) underwent cervical spine reconstruction with a fibula free flap. Average age was 52.3 years old with an age range of 12–79 years. There were six males (46.1%) and seven females (53.8%). The most common defect etiology was infection (n = 6, 46.1%). Most commonly involved cervical spine level of the defect was C5 (n = 10) followed by C6 (n = 9) and C4 (n = 8). The majority of reconstructed defects spanned three or more cervical levels, (n = 9, 69.2%). Facial artery was the most common arterial anastomosis (n = 8). Eight patients (61.5%) required a tracheostomy during their postoperative course. None of the patients had symptomatic or radiographic nonunion.ConclusionThis case series demonstrates that a vascularized fibula flap is a potential reconstructive option for cervical spine defects, especially in defects greater than three cervical levels, in the setting of infection, and previously radiated patients.Level of Evidence4 Laryngoscope, 134:4923–4928, 2024
Microvascular reconstruction of midface osteoradionecrosis
Wax, Mark K. , Amin, Dev , Kane, Anne C. , Cannady, Steven B., Tasche, Kendall K. , DiLeo, Michael, Lander, Daniel P. , Pipkorn, Patrik , Sweeny, Larissa , Konuthula, Neeraja , Wax, Mark K , Kane, Anne C , Cannady, Steve B , Tasche, Kendall, Kejner, Alexandra E , Sweeny, Larissa , Jackson, Ryan S. , Curry, Joseph , Yang, Sara

Head & Neck | June 7, 2024 | Volume: 46 | Issue: 11 | Pages: 2824-2833

10.1002/hed.27824 Get It

AbstractBackgroundHead and neck osteoradionecrosis (ORN) of the midface requiring free flap (FF) reconstruction is uncommon. This multi‐institutional study was designed to review outcomes for this rare patient population.MethodsRetrospective multi‐institutional review of FF reconstruction for midface ORN (2005–2022; n = 54).ResultsThe FF survival rate was 87% (n = 54). Patients were less likely to be tolerating a regular diet at 3 months postoperative if they had a preoperative history of prior head and surgery (80% vs. 95%; p = 0.02), a pathologic fracture (50% vs. 90%; p = 0.04), exposed bone intraorally (43% vs. 94%; p = 0.002), or a fistula (67% vs. 96%; p = 0.03). Mean albumin was higher in patients whose FF survived (3.6 ± 0.5 vs. 2.7 ± 1.4; p = 0.03). Patients with low prealbumin were more likely to undergo a hematoma evacuation (27% vs. 0%; p = 0.02).ConclusionIn this series of midface ORN requiring FF reconstruction preoperative nutritional status impacted postoperative complications. Preoperative occurrence of a fistula, pathologic fracture, and intraoral bone exposure correlated with decreased tolerance of a regular diet following reconstruction.
Microvascular Free Flap Outcomes in Maxillectomy Defects from Invasive Fungal Sinusitis
Rao, Shilpa M., Knott, P. Daniel , Sweeny, Larissa , Domack, Aaron , Tang, Alice , Patel, Rusha , Pittman, Amy , Gardner, James Reed , Moreno, Mauricio A. , Sunde, Jumin , Cave, Taylor B., Knight, Nicolaus D., Greene, Ben, Pipkorn, Patrik , Joshi, Arjun S. , Ji, Keven Seung Yong , Yang, Sara , Wax, Mark K. , Thomas, Carissa M. , Gardner, J Reed , Chang, Brent A , Wax, Mark K , Thomas, Carissa M , Sweeny, Larissa , Rao, Shilpa M., Thakkar, Punam , Chang, Brent A.

The Laryngoscope | September 29, 2023 | Volume: 134 | Issue: 4 | Pages: 1642-1647

10.1002/lary.31081 Get It

ObjectivesMicrovascular free tissue transfer is routinely used for reconstructing midface defects in patients with malignancy, however, studies regarding reconstructive outcomes in invasive fungal sinusitis (IFS) are lacking. We aim to describe outcomes of free flap reconstruction for IFS defects, determine the optimal time to perform reconstruction, and if anti‐fungal medications or other risk factors of an immunocompromised patient population affect reconstructive outcomes.MethodsRetrospective review of reconstruction for IFS (2010–2022). Age, BMI, hemoglobin A1c, number of surgical debridements, and interval from the last debridement to reconstruction were compared between patients with delayed wound healing versus those without. Predictor variables for delayed wound healing and the effect of time on free flap reconstruction were analyzed.ResultsTwenty‐seven patients underwent free flap reconstruction for IFS. Three patients were immunocompromised from leukemia and 21 had diabetes mellitus (DM). Patients underwent an average of four surgical debridements for treatment of IFS. The interval from the last IFS debridement to flap reconstruction was 5.58 months (±5.5). Seven flaps (25.9%) had delayed wound healing. A shorter interval of less than 2 months between the last debridement for IFS and reconstructive free flap procedure was associated with delayed wound healing (Fisher Exact Test p = 0.0062). Other factors including DM, BMI, HgA1c, and bone reconstruction were not associated with delayed wound healing.ConclusionPatients with maxillectomy defects from IFS can undergo microvascular‐free flap reconstruction with good outcomes while on anti‐fungal medication. Early reconstruction in the first 2 months after the last IFS debridement is associated with delayed wound healing.Level of Evidence4 Laryngoscope, 134:1642–1647, 2024
Superior Semicircular Canal Dehiscence Syndrome Following Head Trauma: A Multi‐institutional Review
McCrary, Hilary C. , Babajanian, Eric E. , Patel, Neil S. , Yang, Sara , Kircher, Matthew L., Carlson, Matthew L. , Gurgel, Richard K. , Gurgel, Richard Klaus

The Laryngoscope | July 17, 2021 | Volume: 131 | Issue: 11 | Pages: No page available

10.1002/lary.29751 Get It

ObjectiveTo evaluate patients who become symptomatic from superior semicircular canal dehiscence (SSCD) following head trauma.Study DesignCase series assessing patients presenting with SSCD after a trauma.MethodsA case series was completed assessing patients presenting with SSCD after trauma. Data from three academic medical centers were evaluated, including the following: imaging, videonystagmography (VNG)/vestibular evoked myogenic potential (VEMP) testing, audiometric assessment, and surgical repair. Outcome measures included the following: 1) Description of audio‐vestibular symptoms, 2) mean pre‐ and post‐operative pure tone average (PTA), word recognition score (WRS), and air bone gap (ABG).ResultsA total of 14 patients were included; 86% were male. Approximately 43% were found to have bilateral SSCD on imaging, with 57% of patients pursuing surgical management. The most common presenting symptoms included pulsatile tinnitus (93%), autophony (79%), and hearing loss (64%). Approximately 36% of patients underwent VNG/VEMP testing, with 83.3% of those demonstrating abnormal results. The mean audiometric findings on the symptomatic side included an air‐conduction PTA of 38.0 dB, bone‐conduction PTA of 24.3 dB, WRS of 81%, and ABG of 17.9 dB. Among patients who underwent surgery (57%), there was no significant change in the air‐conduction PTA, bone‐conduction PTA, or WRS (P > .05). However, there was an improvement in the ABG (preoperative = 22.8 dB versus postoperative = 9.7 dB; P = .005).ConclusionHead trauma may be a potentiating event for SSCD syndrome. This study advances the hypothesis that these patients likely have underlying radiographic SSCD prior to their trauma, and a traumatic event increases in intra‐vestibular or intracranial pressures, unmasking SSCD syndrome.Level of Evidence4 Laryngoscope, 131:E2810–E2818, 2021