Scheithauer, Bernd

Introduction: Angiocentric gliomas (ACG) are low grade, epileptogenic tumors with a good prognosis. Only one case of ACG with anaplastic features has been described. We report two examples. Methods: Routinely processed tissue used for histology, immunochemistry and FISH analysis. Results: Case1: 38‐man Two years chronic, worsening seizures. Resection frontal lobe primary (1995) and recurrence (2007). Case 2: 79 woman. Memory deficit and expressive dysphasia. Enhancing temporal lobe mass. Conclusions: The spectrum of ACG includes ependymal and astrocytic features. High grade transformation is uncommon and evidenced by histology, MIB‐1 elevation, strong p53 reactivity and a complex karyotype. The behavior of anaplstic ACG remains to be determined.