Winslow, Nolan

Salt sensitivity is a major cardiovascular focus, but extremes of sodium (Na + ) intake can affect subject dropout rates. We analyzed dietary compliance and baseline cardiovascular indices in an ongoing genotype‐phenotype protocol in healthy young adults. Study visits followed 5 day consumption of 3 daily Na + levels: normal (150) low (10) and high (400 mmol/day). Compliance was determined by 24‐hour Na + excretion. Vital signs were obtained on each visit. Of the first 30 subjects to date, one was unable to tolerate the low Na + diet due to palatability. Mean ± SE urine Na + excretion was 113 ± 27, 25 ± 18 and 328 ±110 mmol for normal, low, and high Na + , respectively. Low Na + caused a significant weight change of −1.6 ± 2.2 kg from screen. High Na + diet decreased resting HR (−2.7 bpm) and increased 24hr urine volume 25% from the normal Na + diet. No correlation was found between urine indices and weight change in the subjects. This dietary sodium crossover study is generally well‐tolerated with high compliance. Low Na + diet appears to cause weight loss; high Na + causes an increase in urine volume and decrease in HR, but no effects on weight or blood pressure. HL 089331