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Mikos, Antonios G.

https://orcid.org/0000-0002-0709-990X

Mayo Clinic

Rice University

Citations 5

Characterization of partially saturated poly(propylene fumarate) for orthopaedic application
Peter, Susan J., Yaszemski, Michael J. , Suggs, Laura J. , Payne, Richard G., Hayes, Wilson C., Unroe, Marilyn R., Engel, Paul S., Mikos, Antonios G. , Langer, Róbert , Alemany, Lawrence B.

Journal of Biomaterials Science, Polymer Edition | April 7, 2008 | Volume: 8 | Issue: 11 | Pages: 893-904

10.1163/156856297x00074 Get It

Synthesis and Conformational Evaluation of a Novel Gene Delivery Vector for Human Mesenchymal Stem Cells
Saraf, Anita , Hacker, Michael C. , Sitharaman, Balaji , Grande‐Allen, K. Jane , Barry, Michael A. , Mikos, Antonios G. , Barry, Michael A

Biomacromolecules | February 5, 2008 | Volume: 9 | Issue: 3 | Pages: 818-827

10.1021/bm701146f Get It

In Vitro Degradation of a Poly(Propylene Fumarate)/ β -Tricalcium Phosphate Composite Orthopaedic Scaffold
Peter, Susan J., Nolley, Jessica A., Widmer, Markus S., Merwin, J.E., Yaszemski, Michael J. , Yasko, Alan W., Engel, Paul S., Mikos, Antonios G.

Tissue Engineering | January 13, 2007 | Volume: 3 | Issue: 2 | Pages: 207-215

10.1089/ten.1997.3.207 Get It

Biological Activity of rhBMP-2 Released From PLGA Microspheres
Oldham, Jacob B., Lu, Lichun , Zhu, and X., Porter, Blaise D., Hefferan, T. E., Larson, David, Currier, Bradford L. , Mikos, Antonios G. , Yaszemski, Michael J.

Journal of Biomechanical Engineering | July 27, 2002 | Volume: 122 | Issue: 3 | Pages: 289-292

10.1115/1.429662 Get It

Human recombinant bone morphogenetic protein-2 (rhBMP-2) has been proven effective in stimulating the regeneration of bone in both skeletal and extraskeletal locations. Through encapsulation within, and release from, biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) microspheres, a proven vehicle for sustained delivery of various proteins, the local concentrations of rhBMP-2 could be maintained at optimal levels to stimulate bone regeneration and remodeling at the site of healing in diverse clinical settings. Thus the purpose of this work was to investigate the encapsulation of rhBMP-2 in PLGA microspheres and its biologic activity upon release. Using in vitro tests in simulated body fluids, the effect of rhBMP-2 released from PLGA microspheres upon osteoblast cell cultures was found to be statistically similar to the effect produced by positive controls consisting of nonencapsulated aqueous rhBMP-2 in simulated body fluids. This clarifies an important step in skeletal tissue engineering strategies aimed at the use of encapsulated rhBMP-2 to stimulate bone regeneration and remodeling. [S0148-0731(00)01303-0]
Synthesis and Characterization of a Block Copolymer Consisting of Poly(propylene fumarate) and Poly(ethylene glycol)
Suggs, Laura J. , Payne, Richard G., Yaszemski, Michael J. , Mikos, Antonios G. , Alemany, Lawrence B.

Macromolecules | July 26, 2002 | Volume: 30 | Issue: 15 | Pages: 4318-4323

10.1021/ma970312v Get It