Citations 1
Correlation of P53 and Bcl-2 With the Presence of Hpv-16 in Sudanese Female Patients Diagnosed With Cervical Pre-cancerous and Squamous Cell Carcinoma of The Cervix.
Ali, Eman T. , Hassan, Lamis Ahmed, Shafig, Irene R., Mohamed, Areeg Magzoub, Fiamma, Maura , Chacko, Mintu Elsa, Siddig, Emmanuel Edwar , Mohamed, Nouh Saad , Muneer, Mohamed S. , Ahmed, Ayman
No container title available | July 8, 2020 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Objectives The persistence of high-risk Human Papilloma virus-16 (HPV-16) is considered as a predisposing factor for the development of the cervical carcinoma and the prognosis of the disease. However, other multifactorial risk factors including cell proliferation and apoptosis markers were also studied and linked to the development and progression of cervical carcinoma. This study is aiming at investigating the association between the presence of HPV-16 and the expression of p53 and Bcl-2 in benign and malignant cervical lesions using immunohistochemical staining methods. Results A total of 150 cases with different cervical lesions were studied, their age ranges from 34 to 67 years (mean 49.5 ± 6.9). Out of the 150 cases; 97 (64.7%) were malignant, 37 (24.7%) were pre-cancerous and 16 (10.7%) were benign lesions. The association between the expression of Bcl-2 and p53, the different histopathological diagnosis, and the type of lesion was statistically significant (p value < 0.0001) Furthermore the statistical analysis of Bcl-2 expression revealed a significant correlation with the cancer grade (p value = 0.018). Nevertheless, p53 expression showed no association with the cancer grade. Regarding the correlation between the presence of HPV-16 and the markers the results were found to be statistically significant.