Hill, Richard W.

A study was undertaken to determine whether the concentration of histamine in the gastric mucosa changes with feeding, with histamine or vagal stimulation, or after the administration of cortisone. The concentration of histamine in the gastric mucosa was determined in dogs in the fasting state, after ingestion of a meal, after a meal followed by the injection of histamine, during insulin-induced hypoglycemia, and after administration of cortisone. Comparison of the different groups with the fasting series disclosed that no significant change in the mucosal concentration of histamine occurred after the meal, after the meal plus injections of histamine, or after administration of cortisone. Insulin-induced hypoglycemia caused a rise in the concentration of histamine in the mucosa of the body and antrum of the stomach.