Citations 3
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
McDowell, Colleen M , Kizhatil, Krishnakumar , Elliott, Michael H. , Overby, Darryl R. , Sherwood, Joseph M. , Millar, J. Cameron , Kuehn, Markus H. , Zode, Gulab , Acott, Ted S. , Anderson, Michael G. , Bertrand, Jacques, Borrás, Terete, Bovenkamp, Diane E. , Cheng, Lin , Danias, John, Ieso, Michael L. De , Du, Yiqin , Faralli, Jennifer A., Fuchshofer, Rudolf , Ganapathy, Preethi S. , Gong, Haiyan , Hernandez, Humberto , John, Simon W. M. , Kaufman, Paul L., Keller, Kate E. , Kelley, Mary J. , Kelly, Ruth A. , Križaj, David , Kumar, Ajay , Leonard, Brian C. , Liu, Katy C., López, Navita N., Mao, Weiming , Mavlyutov, Timur, McDonnell, Fiona , Mzyk, Philip , Nartey, Andrews , Pasquale, Louis R. , Patel, Gaurang , Pattabiraman, Padmanabhan P. , Peters, Donna M. , Raghunathan, Vijaykrishna, Rao, Ponugoti Vasantha , Rayana, Naga Pradeep , Raychaudhuri, Urmimala, Reina‐Torres, Ester , Rhee, Douglas J. , Chowdhury, Uttio Roy, Samples, John R., Samples, E. Griffen, Sharif, Najam A. , Schuman, Joel S. , Stevenson, Cooper H., Soundararajan, Avinash , Subramanian, Preeti, Sugali, Chenna Kesavulu , Sun, Yang , Torrejon, Karen Y., Vahabikashi, Amir , Vranka, Janice A., Wang, Ting , Willoughby, Colin E. , Chen, Xin , Yun, Hongmin , Fautsch, Michael P. , Tamm, Ernst R. , Clark, Abbot F. , Ethier, C. Ross , Schuman, Joel S , Bhattacharya, Sanjoy K. , Bertrand, Jacques A., Herberg, Samuel , Humphries, Peter , Lieberman, Raquel L. , Liton, Paloma B. , Liu, Yutao , McLellan, Gillian J. , Raghunathan, Vijay Krishna , Rao, Ponugoti Vasantha , Ren, Ruiyi , Sheffield, Val C. , Toris, Carol B. , Zhang, Hao F. , Stamer, William Daniel
Investigative Opthalmology & Visual Science | February 7, 2022 | Volume: 63 | Issue: 2 | Pages: 12
Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway
Philips, Brian J. , Bürki, Sarah, Ryan, John P. , Noda, Kentaro , D’Cunha, Jonathan, D'Cunha, Jonathan, Kumar, Ajay
Oncotarget | July 14, 2020 | Volume: 11 | Issue: 28 | Pages: 2793-2806
Nitrite attenuates mitochondrial impairment and vascular permeability induced by ischemia-reperfusion injury in the lung
Noda, Kentaro , Philips, Brian J. , Velayutham, Murugesan, Gladwin, Mark T. , D’Cunha, Jonathan, Noda, Kentaro , D'Cunha, Jonathan, Kumar, Ajay , Velayutham, Murugesan, Stolz, Donna Beer , Shiva, Sruti S.
American Journal of Physiology-Lung Cellular and Molecular Physiology | February 19, 2020 | Volume: 318 | Issue: 4 | Pages: L580-L591
Primary graft dysfunction (PGD) is directly related to ischemia-reperfusion (I/R) injury and a major obstacle in lung transplantation (LTx). Nitrite ([Formula: see text]), which is reduced in vivo to form nitric oxide (NO), has recently emerged as an intrinsic signaling molecule with a prominent role in cytoprotection against I/R injury. Using a murine model, we provide the evidence that nitrite mitigated I/R-induced injury by diminishing infiltration of immune cells in the alveolar space, reducing pulmonary edema, and improving pulmonary function. Ultrastructural studies support severe mitochondrial impairment in the lung undergoing I/R injury, which was significantly protected by nitrite treatment. Nitrite also abrogated the increased pulmonary vascular permeability caused by I/R. In vitro, hypoxia-reoxygenation (H/R) exacerbated cell death in lung epithelial and microvascular endothelial cells. This contributed to mitochondrial dysfunction as characterized by diminished complex I activity and mitochondrial membrane potential but increased mitochondrial reactive oxygen species (mtROS). Pretreatment of cells with nitrite robustly attenuated mtROS production through modulation of complex I activity. These findings illustrate a potential novel mechanism in which nitrite protects the lung against I/R injury by regulating mitochondrial bioenergetics and vascular permeability.