Citations 1
Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis
Walsh, Kathleen F. , McAulay, Katherine, Lee, Miroku, Vilbrun, Stalz Charles , Mathurin, L, Francois, Daphie, Zimmerman, M J, Kaya, Firat , Zhang, Na-Na, Saito, Kohta , Ocheretina, Oksana , Savić, Radojka M. , Dartois, Véronique , Pape, Jean W. , Nathan, Carl , Fitzgerald, Daniel W. , Walsh, K F , Dartois, V , Nathan, C , Zimmerman, M., Johnson, William D.
Antimicrobial Agents and Chemotherapy | February 17, 2020 | Volume: 64 | Issue: 5 | Pages: No page available
This study was conducted in treatment-naive adults with drug-susceptible pulmonary tuberculosis in Port-au-Prince, Haiti, to assess the safety, bactericidal activity, and pharmacokinetics of nitazoxanide (NTZ). This was a prospective phase II clinical trial in 30 adults with pulmonary tuberculosis. Twenty participants received 1 g of NTZ orally twice daily for 14 days. A control group of 10 participants received standard therapy over 14 days. The primary outcome was the change in time to culture positivity (TTP) in an automated liquid culture system.