Mayo Clinic - AuthorCitation

Human Granulocytic Anaplasmosis—A Systematic Review of Published Cases

Dumic, Igor , Jevtic, Dorde , Veselinovic, Mladjen, Nordstrom, Charles W. , Mogulla, Vanajakshi , Veselinovic, Elmira Mofid, Hudson, Ann, Simeunovic, Gordana , Petcu, Emilia, Ramanan, Poornima , Dumic, Igor , Jevtic, Djordje , Jovanovic, Milan D.

Microorganisms | July 18, 2022 | Volume: 10 | Issue: 7 | Pages: 1433

Anaplasma phagocytophilum is an emerging, Gram-negative, obligate intracellular pathogen that is transmitted by a tick vector. Human infection ranges from asymptomatic to severe disease that can present with pancytopenia, multiorgan failure, and death. The aim of this systematic review is to analyze case reports and case series reported over the last two decades in peer-reviewed journals indexed in the Medline/PubMed database according to the PRISMA guidelines. We found 110 unique patients from 88 case reports and series. The most common mode of transmission was tick bite (60.9%), followed by blood transfusion (8.2%). Infection was acquired by blood transfusion in nearly half (42%) of the immunocompromised patients. Most patients reported fever (90%), followed by constitutional (59%) and gastrointestinal symptoms (56%). Rash was present in 17% of patients, much higher than in previous studies. Thrombocytopenia was the most common laboratory abnormality (76%) followed by elevated aspartate aminotransferase (AST) (46%). The diagnosis was most commonly established using whole-blood polymerase chain reaction (PCR) in 76% of patients. Coinfection rate was 9.1% and Borrelia burgdorferi was most commonly isolated in seven patients (6.4%). Doxycycline was used to treat 70% of patients but was only used as an empiric treatment in one-third of patients (33.6%). The overall mortality rate was 5.7%, and one patient died from trauma unrelated to HGA. The mortality rates among immunocompetent and immunocompromised patients were 4.2% (n = 4/95) and 18.2% (n = 2/11), respectively. Four of the six patients who died (66.6%) received appropriate antibiotic therapy. Among these, doxycycline was delayed by more than 48 h in two patients.

Septic Shock and Purpura Fulminans Due to Streptococcus pneumoniae Bacteremia in an Unvaccinated Immunocompetent Adult: Case Report and Review

Djurdjevic, Nikola, Taweesedt, Pahnwat , LaNou, Abigail T. , Radovanovic, Milan , Patel, Janki, Veselinovic, Mladjen, McDermott, Wendy, Dumic, Igor , Paulson, Margaret, LaNou, Abigail, Patel, Janki N, McDermott, Wendy R, Dumic, Igor , Djurdjevic, Nikola, Paulson, Margaret R.

American Journal of Case Reports | May 12, 2020 | Volume: 21 | Issue: No issue available | Pages: No page available

10.12659/ajcr.923266

Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre’s Syndrome

Radovanović, Nataša , Dumic, Igor , Veselinovic, Mladjen, Burger, Susanne, Alempijević, Tamara , Nordstrom, Charles W. , Niendorf, Eric, Ramanan, Poornima , Alempijevic, Tamara , Dumic, Igor

Case Reports in Infectious Diseases | January 13, 2020 | Volume: 2020 | Issue: No issue available | Pages: 1-6

10.1155/2020/9237267

Liver abscess associated with suppurative portal vein thrombosis (pylephlebitis) secondary to Fusobacterium necrophorum has been rarely reported. It is considered to be an abdominal variant of Lemierre’s syndrome associated with significant morbidity and mortality. We report a case of 69-year-old man who developed liver abscess and pylephlebitis due to F. necrophorum with an unclear source of infection. We discuss the pathogenesis, diagnosis, and treatment strategy for this entity, with a review of previously published cases of pyelephlebitis due to F. necrophorum in regard to their clinical presentation and outcome.