Citations 2
Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC
Olsen, Elise A. , Whittaker, Sean , Willemze, Rein , Pinter‐Brown, Lauren , Foss, Francine M. , Schwartz, Lawrence , Guitart, Joan , Zic, John A., Wood, Gary S. , Ai, Wei , Gru, Alejandro A. , Guenova, Emmanuella , Hodak, Emmilia , Hoppe, Richard T. , Lechowicz, Mary Jo , Ortiz‐Romero, Pablo L. , Papadavid, Evangelia , Pittelkow, Mark R. , Prince, H. Miles , Sanches, José Antônio , Sugaya, Makoto , Vermeer, Maarten H. , Knobler, Robert , Stadler, Rudolf , Scarisbrick, Julia , Foss, Francine , Kim, Youn H , Gru, Alejandro , Guenova, Emmanuella , Ortiz-Romero, Pablo , Prince, H Miles , Sanches, Jose Antonio , Sugaya, Makoto , Vermeer, Maarten , Zain, Jasmine , Knobler, Robert , Stadler, Rudolf , Scarisbrick, Julia , Hoppe, Richard T , Geskin, Larisa J. , Horwitz, Sarah McCue , Duvic, Madeleine , Ai, Wei, Girardi, Michael , Kempf, Werner , Kim, Ellen , Quaglino, Pietro , Bagot, Martine
Blood | November 11, 2021 | Volume: 140 | Issue: 5 | Pages: 419-437
Abstract The number of patients with primary cutaneous lymphoma (PCL) relative to other non-Hodgkin lymphomas (NHLs) is small and the number of subtypes large. Although clinical trial guidelines have been published for mycosis fungoides/Sézary syndrome, the most common type of PCL, none exist for the other PCLs. In addition, staging of the PCLs has been evolving based on new data on potential prognostic factors, diagnosis, and assessment methods of both skin and extracutaneous disease and a desire to align the latter with the Lugano guidelines for all NHLs. The International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous LymphomaConsortium (USCLC), and the Cutaneous Lymphoma Task Force of the European Organization for the Research and Treatment of Cancer (EORTC) now propose updated staging and guidelines for the study design, assessment, endpoints, and response criteria in clinical trials for all the PCLs in alignment with that of the Lugano guidelines. These recommendations provide standardized methodology that should facilitate planning and regulatory approval of new treatments for these lymphomas worldwide, encourage cooperative investigator-initiated trials, and help to assess the comparative efficacy of therapeutic agents tested across sites and studies.
Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Can
Olsen, Elise A. , Vonderheid, Eric C. , Pimpinelli, Nicola , Knobler, Robert , Zackheim, Herschel, Estrach, Teresa , Lamberg, Stanford, Wood, Gary S. , Dummer, Reinhard , Burg, Günter , Heald, Peter, Pittelkow, Mark R. , Bernengo, M.G., Sterry, Wolfram, Laroche, L. , Trautinger, Franz , Whittaker, Sean , Willemze, Rein , Kim, Youn , Zackheim, Herschel, Duvic, Madeleine , Lamberg, Stanford, Ranki, Annamari , Sterry, Wolfram
Blood | May 31, 2007 | Volume: 110 | Issue: 6 | Pages: 1713-1722
Abstract The ISCL/EORTC recommends revisions to the Mycosis Fungoides Cooperative Group classification and staging system for cutaneous T-cell lymphoma (CTCL). These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides (MF) and Sézary syndrome (SS) since the 1979 publication of the original guidelines, to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS, and to provide a platform for tracking other variables of potential prognostic significance. Moreover, given the difference in prognosis and clinical characteristics of the non-MF/non-SS subtypes of cutaneous lymphoma, this revision pertains specifically to MF and SS. The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions.