George, Ilena
https://orcid.org/0000-0001-7863-8539
Mayo Clinic
Icahn School of Medicine at Mount Sinai
Citations 2
Cerebellar Volume Loss in Radiologically Isolated Syndrome (P5.2-036)
Mendili, Mohamed‐Mounir El, Azevedo, Christina , Kantarci, Orhun H. , Pelletier, Daniel , George, Ilena , Lebrun‐Frénay, Christine , Sıva, Aksel , Okuda, Darin T. , Inglese, Matilde
Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available
Cerebellar volume loss in radiologically isolated syndrome
George, Ilena , Mendili, Mohamed Mounir El , Inglese, Matilde , Azevedo, Christina , Kantarci, Orhun H. , Sıva, Aksel , Okuda, Darin T. , Pelletier, Daniel , Siva, Aksel , Okuda, Darin T , Lebrun‐Frénay, Christine
Multiple Sclerosis Journal | November 4, 2019 | Volume: 27 | Issue: 1 | Pages: 130-133
Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.