Citations 2
Identification of the Molecular Genetic Defect of Patients With Methemoglobin M Kankakee (M-Iwate), 87 (F8) His → Tyr: Evidence for an Electrostatic Model of M Hemoglobin Assembly
Ameri, Afshin, Fairbanks, Virgil F., Yanik, Greg, Mahdi, F., Thibodeau, Stephen N. , Boxer, Laurence A., McDonagh, Kevin T., McCormick, Daniel
Blood | October 14, 2019 | Volume: 94 | Issue: 5 | Pages: 1825-1826
AbstractWe determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, 87 (F8) His → Tyr] resides in the 1-globin gene. The proportion of Hb M observed is higher than that predicted for an 1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative β-globin chains with the M-globin chains that are more electropositive than normal -globin chains.
Identification of the Molecular Genetic Defect of Patients With Methemoglobin M Kankakee (M-Iwate), 87 (F8) His → Tyr: Evidence for an Electrostatic Model of M Hemoglobin Assembly
Ameri, Afshin, Fairbanks, Virgil F., Yanik, Greg, Mahdi, F., Thibodeau, Stephen N. , Boxer, Laurence A., McDonagh, Kevin T., McCormick, Daniel
Blood | October 11, 2019 | Volume: 94 | Issue: 5 | Pages: 1825-1826
10.1182/blood.v94.5.1825.417k24_1825_1826
We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, 87 (F8) His → Tyr] resides in the 1-globin gene. The proportion of Hb M observed is higher than that predicted for an 1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative β-globin chains with the M-globin chains that are more electropositive than normal -globin chains.