Citations 2
Cryptic t(6;11) KMT2A rearrangement in a pediatric acute myeloid leukemia patient detected by next‐generation sequencing and dual‐fusion FISH analysis
Raghunandan, Sharmila , Jain, Juhi , Saxe, Debra , Pauly, Melinda , Aljudi, Ahmed, Raikar, Sunil S. , Raikar, Sunil S , Ketterling, Rhett P. , Carter, Alexis B.
Pediatric Blood & Cancer | November 12, 2021 | Volume: 69 | Issue: 3 | Pages: No page available
Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
Eason, Ashley C., Bunting, Silvia T., Saxe, Debra , Sabnis, Himalee S. , Peterson, Jess F , Sabnis, Himalee S , Peterson, Jess F.
Case Reports in Hematology | September 8, 2019 | Volume: 2019 | Issue: No issue available | Pages: 1-4
Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML.