Frangieh, Antonio H.
https://orcid.org/0000-0001-6645-6367
Mayo Clinic
German Centre for Cardiovascular Research
Citations 2
Impact of Aspirin on Takotsubo Syndrome: A Propensity Score-Based Analysis of the InterTAK Registry
Gili, Sebastiano , Bertaina, Maurizio , Iannaccone, Mario , Cammann, Victoria L. , Vece, Davide Di , Saglietto, Andrea , Szawan, Konrad A. , Frangieh, Antonio H. , Boffini, Beatrice, Annaratone, Margherita, Sarcon, Annahita, Levinson, Rena A. , Franke, Jennifer , Napp, L. Christian , Münzel, Thomas , Knorr, Maike, Heiner, Susanne, Katus, Hugo A. , Burgdorf, Christof , Tschöpe, Carsten , Pieske, Burkert , Rajan, Lawrence, Michels, Guido, Pfister, Roman , Cuneo, Alessandro , Jacobshagen, Claudius, Karakas, Mahir , Köenig, Wolfgang , Rottbauer, Wolfgang , Said, Samir M., Banning, Adrian , Cuculi, Florim , Kobza, Richard , Fischer, Thomas, Vasankari, Tuija , Airaksinen, Juhani , Opolski, Grzegorz , Dworakowski, Rafał , MacCarthy, Philip , Osswald, Stefan , Galiuto, Leonarda , Franz, Wolfgang M., Empen, Klaus , Felix, Stephan B. , El‐Battrawy, Ibrahim , Akın, İbrahim , Borggrefe, Martin, Kozel, Martin , Widimský, Petr , Gilyarova, Ekaterina, Gilyarov, Mikhail , Biondi‐Zoccai, Giuseppe , Winchester, David E. , Ukena, Christian , Prasad, Abhiram , Böhm, Michael , Bossone, Eduardo , Citro, Rodolfo , Lüscher, Thomas F. , Ghadri, Jelena R. , Templin, Christian , Gilyarov, Mikhail , Bossone, Eduardo , Citro, Rodolfo , El-Battrawy, Ibrahim , Prasad, Abhiram , Tschöpe, Carsten , Koenig, Wolfgang , Banning, Adrian , Kobza, Richard , Gilyarov, Mikhail , Ukena, Christian , D’Ascenzo, Fabrizio , Kato, Ken , Jaguszewski, Miłosz , Noutsias, Michel , Schunkert, Heribert , Thiele, Hölger , Bauersachs, Johann , Hasenfuß, Gerd , Braun-Dullaeus, Ruediger Christian , Kaiser, Christoph A. , Crea, Filippo , Dichtl, Wolfgang , Delmas, Clément , Lairez, Olivier , Horowitz, John D. , Toušek, Petr , Shilova, Alexandra S. , Neuhaus, Michael, Bax, Jeroen J. , Mario, Carlo Di , Gasparini, Mauro , Ruschitzka, Frank T. , Rinaldi, Mauro , Ferrari, Gaetano Maria De
European Journal of Heart Failure | December 21, 2019 | Volume: 22 | Issue: 2 | Pages: 330-337
Abstract Aims The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78–1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
Cammann, Victoria L. , Sarcon, Annahita, Ding, Katharina J., Kato, Ken , Vece, Davide Di , Szawan, Konrad A. , Gili, Sebastiano , Jurisic, Stjepan , Bacchi, Beatrice , Micek, Jozef, Frangieh, Antonio H. , Napp, L. Christian , Bossone, Eduardo , Citro, Rodolfo , Franke, Jennifer , Knorr, Maike, Heiner, Susanne, Burgdorf, Christof , Köenig, Wolfgang , Tschöpe, Carsten , Rajan, Lawrence, Michels, Guido, Pfister, Roman , Cuneo, Alessandro , Jacobshagen, Claudius, Karakas, Mahir , Banning, Adrian , Cuculi, Florim , Kobza, Richard , Fischer, Thomas, Vasankari, Tuija , Airaksinen, Juhani , Dworakowski, Rafał , Osswald, Stefan , Galiuto, Leonarda , Dichtl, Wolfgang , Delmas, Clément , Horowitz, John D. , Kozel, Martin , Widimský, Petr, Winchester, David E. , Gilyarova, Ekaterina, Gilyarov, Mikhail , El‐Battrawy, Ibrahim , Akın, İbrahim , Ukena, Christian , Pieske, Burkert , Rottbauer, Wolfgang , Opolski, Grzegorz , MacCarthy, Philip , Felix, Stephan B. , Borggrefe, Martin , Crea, Filippo , Katus, Hugo A. , Münzel, Thomas , Böhm, Michael , Prasad, Abhiram , Shinbane, Jerold S., Lüscher, Thomas F. , Ghadri, Jelena R. , Templin, Christian , Gilyarov, Mikhail , Bossone, Eduardo , Citro, Rodolfo , El-Battrawy, Ibrahim , Prasad, Abhiram , Tschöpe, Carsten , Koenig, Wolfgang , Banning, Adrian , Kobza, Richard , Gilyarov, Mikhail , Ukena, Christian , Seifert, Burkhardt , Jaguszewski, Miłosz , D’Ascenzo, Fabrizio , Noutsias, Michel , Thiele, Hölger , Kaiser, Christoph A. , Lairez, Olivier , Toušek, Petr , Shilova, Alexandra S. , Bauersachs, Johann , Hasenfuß, Gerd , Braun-Dullaeus, Ruediger Christian , Mario, Carlo Di , Schunkert, Heribert , Bax, Jeroen J. , Ruschitzka, Frank T.
Journal of the American Heart Association | July 17, 2019 | Volume: 8 | Issue: 15 | Pages: No page available
Background Clinical characteristics and outcomes of takotsubo syndrome ( TTS ) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short‐ and long‐term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short‐ and long‐term mortality. A subanalysis was performed comparing long‐term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long‐term mortality was higher in patients with malignancy ( P <0.001), while short‐term outcome was comparable ( P =0.17). In a subanalysis, long‐term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies ( P =0.13). Malignancy emerged as an independent predictor of long‐term mortality. Conclusions A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS , and therefore, appropriate screening for malignancy should be considered in these patients. Clinical Trial Registration URL : http://www.clinicaltrial.gov . Unique identifier: NCT 01947621.