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Graff, Caroline

https://orcid.org/0000-0002-9949-2951

Mayo Clinic

Karolinska Institutet

Citations 34

P3‐258: Further evidence of genetic association between SORL1 and Alzheimer's disease
Meng, Yan , Wakutani, Yosuke, Zou, Fanggeng, Moreno, Danielle , Cheng, Rong , Duara, Ranjan , Petersen, Ronald , Younkin, Steven G. , Mayeux, Richard , Rogaeva, Ekaterina A. , Lee, Joseph H. , Sorbi, Sandro , Bruni, Amalia C. , Duara, Ranjan , Graff, Caroline , Dickson, Dennis W. , Farrer, Lindsay A. , George‐Hyslop, Peter St

Alzheimer's & Dementia | July 24, 2008 | Volume: 4 | Issue: 4S_Part_18 | Pages: No page available

10.1016/j.jalz.2008.05.1826 Get It

P1–360: Analysis of variants in UBQLN1 for association with late onset Alzheimer's disease (LOAD)
Zou, Fanggeng, Carrasquillo, Minerva M. , Younkin, Samuel , Younkin, Linda H., Petersen, Ronald, Younkin, Steven G., Watson, Christopher Mark , Carrasquillo, Minerva M. , Graff, Caroline

Alzheimer's & Dementia | August 17, 2006 | Volume: 2 | Issue: 3S_Part_7 | Pages: No page available

10.1016/j.jalz.2006.05.738 Get It

P1–310: Late onset Alzheimer's disease (LOAD) susceptibility alleles in the insulin–degrading–enzyme gene (IDE) and other Aβ–degrading enzymes
Carrasquillo, Minerva M. , Kashino, Mariah R., Wilcox, Samantha L., Howard, Melissa E., Li, Ma, Zou, Fanggeng, Ertekin‐Taner, Nilüfer , Allen, Mariet , Younkin, Linda H., Petersen, Ronald C. , Younkin, Steven G., Carrasquillo, Minerva M. , Younkin, Samuel , Dincman, Toros A. , Stanton, Chloë M. , Watson, Christopher Mark , Graff, Caroline

Alzheimer's & Dementia | August 17, 2006 | Volume: 2 | Issue: 3S_Part_7 | Pages: No page available

10.1016/j.jalz.2006.05.688 Get It

Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Ertekin‐Taner, Nilüfer , Younkin, Linda H., Eckman, Christopher B., Adamson, Jennifer, Hutton, Michael , Younkin, Steven G., Graff, Caroline , Baker, Matthew , Ronald, James , Blangero, John

Science | July 27, 2002 | Volume: 290 | Issue: 5500 | Pages: 2303-2304

10.1126/science.290.5500.2303 Get It

Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.