Citations 1
Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium
Manion, Maura , Dimitrova, Dimana , Pei, Luxin , Gea‐Banacloche, Juan , Lisco, Andrea , Zerbe, Christa S. , Freeman, Alexandra F. , Holland, Steven M. , Kanakry, Christopher G. , Kanakry, Jennifer A. , Zelazny, Adrian M. , Sereti, Irini
Clinical Infectious Diseases | June 11, 2019 | Volume: 70 | Issue: 4 | Pages: 676-679
Abstract Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.