Citations 1
Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2019
Brown, Patrick A. , Wieduwilt, Matthew J. , Wang, Eunice S. , Fathi, Amir T. , Litzow, Mark R. , Aoun, Patricia, Bhatnagar, Bhavana , Boyer, Michael W., Bryan, Teresa , Burke, Patrick W. , Coccia, Peter F., Coutré, Steven , Kirby, Suzanne, Massaro, Stephanie, Mattison, Ryan J. , Oluwole, Olalekan O. , Papadantonakis, Nikolaos , Park, Jae H. , Uy, Geoffrey L. , Gregory, Kristina M., Ogba, Ndiya , Wang, Eunice S. , Oluwole, Olalekan O , Uy, Geoffrey , Logan, Aaron C , DeAngelo, Daniel J. , Cassaday, Ryan D. , Advani, Anjali S. , Jain, Nitin , Liu, Arthur , Rubnitz, Jeffrey E. , Shah, Bijal
Journal of the National Comprehensive Cancer Network | May 22, 2019 | Volume: 17 | Issue: 5 | Pages: 414-423
Survival outcomes for older adults with acute lymphoblastic leukemia (ALL) are poor and optimal management is challenging due to higher-risk leukemia genetics, comorbidities, and lower tolerance to intensive therapy. A critical understanding of these factors guides the selection of frontline therapies and subsequent treatment strategies. In addition, there have been recent developments in minimal/measurable residual disease (MRD) testing and blinatumomab use in the context of MRD-positive disease after therapy. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines for ALL regarding upfront therapy in older adults and MRD monitoring/testing in response to ALL treatment.