Citations 1
RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation
Anguita-Alonso, Paloma , Giacometti, Andrea , Cirioni, Oscar, Ghiselli, Roberto , Orlando, Fiorenza , Saba, Vittorio, Scalise, Giorgio, Ševo, Milica, Tuzova, Marina, Patel, Robin , Balaban, Naomi, Patel, Robin
Antimicrobial Agents and Chemotherapy | November 21, 2006 | Volume: 51 | Issue: 7 | Pages: 2594-2596
ABSTRACT Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.