Citations 1
Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Lee, Lisa Eunyoung , Chan, Jillian, Nevill, Emilie, Soares, Adam, Vavasour, Irene M. , Garren, Hideki, Clayton, David , Tam, Roger , Kolind, Shannon , Carruthers, Robert , MacMillan, Erin L. , Keegan, B. Mark , Traboulsee, Anthony , Kollind, Shannon H , Lee, Lisa Eunyoung , Tam, Roger
Multiple Sclerosis Journal - Experimental, Translational and Clinical | January 16, 2019 | Volume: 5 | Issue: 1 | Pages: No page available
Background Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. Objective To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. Methods Case report. Results Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. Conclusion Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.