Citations 1
13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N -Butyl- N -(4-hydroxybutyl)nitrosamine
Grubbs, Clinton J., Moon, Richard C., Squire, Robert A., Farrow, George M., Stinson, Sherman F., Goodman, Dawn G., Brown, Charles, Sporn, Michael B.
Science | October 5, 2006 | Volume: 198 | Issue: 4318 | Pages: 743-744
Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N -butyl- N -(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.