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3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Yan, Yuqian , Shao, Jingwei , Ding, Donglin , Pan, Yunqian , Tran, Phuc , Li, Hongyu , Huang, Haojie , Huang, Rui , Yan, Wei , Wang, Zhenyu

Mayo Clinic

Chemical Communications | January 26, 2022 | Volume: 58 | Issue: 14 | Pages: 2383-2386

10.1039/d1cc06525d | PMID 35080528 Get It

In this study, we discovered 3-aminophthalic acid as a new ligand of cereblon (CRBN) E3 ubiquitin ligase and developed a phthalic acid-based O’PROTAC for ERG destruction, expanding the pool of ligands for development of PROTACs, especially O’PROTACs.