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15 citation(s) found for "Sliwa, K".

Making a difference: 5 years of Cardiac Surgery Intersociety Alliance (CSIA)
Bolman, R.M., Zilla, Peter , Boateng, Percy , Bavaria, Joseph E. , Pomar, J. L. , Chotivatanapong, T., Eisele, Julie, Enumah, Zachary Obinna , Farkas, Emily A. , Higgins, Robert , Zilla, P , Boateng, P , Sliwa, K , Dearani, Joseph A. , Kumar, Sanjeev , Sliwa, Karen , Podesser, Bruno Karl , Kofidis, Theo , Zühlke, Liesl

Mayo Clinic

Asian Cardiovascular and Thoracic Annals | June 14, 2024 | Volume: 32 | Issue: 5 | Pages: 271-284

10.1177/02184923241259191 | PMID 38872357 Get It

Informed by the almost unimaginable unmet need for cardiac surgery in the developing regions of the world, leading surgeons, cardiologists, editors in chief of the major cardiothoracic journals as well as representatives of medical industry and government convened in December 2017 to address this unacceptable disparity in access to care. The ensuing “Cape Town Declaration” constituted a clarion call to cardiac surgical societies to jointly advocate the strengthening of sustainable, local cardiac surgical capacity in the developing world. The Cardiac Surgery Intersociety Alliance (CSIA) was thus created, comprising The Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS), the European Association for Cardio-Thoracic Surgery (EACTS) and the World Heart Federation (WHF). The guiding principle was advocacy for sustainable cardiac surgical capacity in low-income countries. Summary Informed by the almost unimaginable unmet need for cardiac surgery in the developing regions of the world, leading surgeons, cardiologists, editors in chief of the major cardiothoracic journals as well as representatives of medical industry and government convened in December 2017 to address this unacceptable disparity in access to care. The ensuing “Cape Town Declaration” constituted a clarion call to cardiac surgical societies to jointly advocate the strengthening of sustainable, local cardiac surgical capacity in the developing world. The Cardiac Surgery Intersociety Alliance (CSIA) was thus created, comprising The Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS), the European Association for Cardio-Thoracic Surgery (EACTS) and the World Heart Federation (WHF). The guiding principle was advocacy for sustainable cardiac surgical capacity in low-income countries. As a first step, a global needs assessment confirmed rheumatic heart disease as the overwhelming pathology requiring cardiac surgery in these regions. Subsequently, CSIA published a request for proposals to support fledgling programmes that could demonstrate the backing by their governments and health care institution. Out of 11 applicants, and following an evaluation of the sites, including site visits to the 3 finalists, Mozambique and Rwanda were selected as the first Pilot Sites. Subsequently, a mentorship and training agreement was completed between Mozambique and the University of Cape Town, a middle-income country with a comparable burden of rheumatic heart disease. The agreement entails regular video calls between the heart teams, targeted training across all aspects of cardiac surgery, as well as on-site presence of mentoring teams for complex cases with the strict observance of ‘assisting only’. In Rwanda, Team Heart, a US and Rwanda-based non-governmental organization (NGO) that has been performing cardiac surgery in Rwanda and helping to train the cardiac surgery workforce since 2008, has agreed to continue providing mentorship for the local team and to assist in the establishment of independent cardiac surgery with all that entails. This involves intermittent virtual conferences between Rwandan and US cardiologists for surgical case selection. Five years after CSIA was founded, it’s ‘Seal of Approval’ for the sustainability of endorsed programmes in Mozambique and Rwanda has resulted in higher case numbers, a stronger government commitment, significant upgrades of infrastructure, the nurturing of generous consumable donations by industry and the commencement of negotiations with global donors for major grants. Extending the CSIA Seal to additional deserving programmes could further align the international cardiac surgical community with the principle of local cardiac surgery capacity-building in developing countries.
Making a difference: 5 years of Cardiac Surgery Intersociety Alliance (CSIA)
Bolman, R. Morton , Zilla, Peter , Boateng, Percy , Bavaria, Joseph E. , Pomar, J. L. , Chotivatanapong, Taweesak, Sliwa, Karen , Eisele, Julie, Enumah, Zachary Obinna , Farkas, Emily A. , Zühlke, Liesl , Higgins, Robert , Zilla, P , Boateng, P , Sliwa, K , Beyersdorf, Friedhelm , Dearani, Joseph A. , Kumar, Sanjeev , Podesser, Bruno Karl , Kofidis, Theo

Mayo Clinic

European Journal of Cardio-Thoracic Surgery | June 10, 2024 | Volume: 65 | Issue: 6 | Pages: No page available

10.1093/ejcts/ezae048 | PMID 38856237 Get It

Summary Informed by the almost unimaginable unmet need for cardiac surgery in the developing regions of the world, leading surgeons, cardiologists, editors in chief of the major cardiothoracic journals as well as representatives of medical industry and government convened in December 2017 to address this unacceptable disparity in access to care. The ensuing “Cape Town Declaration” constituted a clarion call to cardiac surgical societies to jointly advocate the strengthening of sustainable, local cardiac surgical capacity in the developing world. The Cardiac Surgery Intersociety Alliance (CSIA) was thus created, comprising The Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS), the European Association for Cardio-Thoracic Surgery (EACTS) and the World Heart Federation (WHF). The guiding principle was advocacy for sustainable cardiac surgical capacity in low-income countries. As a first step, a global needs assessment confirmed rheumatic heart disease as the overwhelming pathology requiring cardiac surgery in these regions. Subsequently, CSIA published a request for proposals to support fledgling programmes that could demonstrate the backing by their governments and health care institution. Out of 11 applicants, and following an evaluation of the sites, including site visits to the 3 finalists, Mozambique and Rwanda were selected as the first Pilot Sites. Subsequently, a mentorship and training agreement was completed between Mozambique and the University of Cape Town, a middle-income country with a comparable burden of rheumatic heart disease. The agreement entails regular video calls between the heart teams, targeted training across all aspects of cardiac surgery, as well as on-site presence of mentoring teams for complex cases with the strict observance of ‘assisting only’. In Rwanda, Team Heart, a US and Rwanda-based non-governmental organization (NGO) that has been performing cardiac surgery in Rwanda and helping to train the cardiac surgery workforce since 2008, has agreed to continue providing mentorship for the local team and to assist in the establishment of independent cardiac surgery with all that entails. This involves intermittent virtual conferences between Rwandan and US cardiologists for surgical case selection. Five years after CSIA was founded, its ‘Seal of Approval’ for the sustainability of endorsed programmes in Mozambique and Rwanda has resulted in higher case numbers, a stronger government commitment, significant upgrades of infrastructure, the nurturing of generous consumable donations by industry and the commencement of negotiations with global donors for major grants. Extending the CSIA Seal to additional deserving programmes could further align the international cardiac surgical community with the principle of local cardiac surgery capacity-building in developing countries.
A qualitative study of strategies to improve occupational well‐being in physical medicine and rehabilitation physicians
Amano, Alexis , Trockel, Mickey , Menon, Nikitha K. , Sliwa, James A. , Kinney, Carolyn L. , Knowlton, Tiffany, Stautzenbach, Thomas E., Shanafelt, Tait D. , Sliwa, James , Kinney, Carolyn , Verduzco-Gutierrez, Monica , Shanafelt, Tait D , Makowski, Maryam S , Wang, Hanhan , Weinstein, Stuart L. , Paganoni, Sabrina , Verduzco‐Gutierrez, Monica , Kennedy, David J.

Mayo Clinic

PM&R | June 5, 2024 | Volume: 16 | Issue: 7 | Pages: 687-699

10.1002/pmrj.13189 | PMID 38837667 Get It

Abstract Background Physiatry is a specialty with high rates of burnout. Although organizational strategies to combat burnout are key, it is also important to understand strategies that individual physiatrists can use to address burnout. Objective To identify changes that resulted in improvement of occupational well‐being of physiatrists over a 6‐ to 9‐month period. Design We employed two quantitative surveys spaced 6 to 9 months apart to identify physiatrists who experienced meaningful improvement in occupational burnout and/or professional fulfillment between the two survey timepoints. These physiatrists were subsequently recruited to participate in a qualitative study using semi‐structured interviews to identify changes that respondents felt contributed to improvements in burnout and professional fulfillment. Setting Online surveys and interviews. Participants Physiatrists in the American Academy of Physical Medicine and Rehabilitation (AAPM&R) Membership Masterfile. Main Outcome Measure Burnout and professional fulfillment were assessed using the Stanford Professional Fulfillment Index. Results One hundred twelve physiatrists responded to the baseline and follow‐up surveys. Of these, 35 were eligible for interviews based on improvements in the Stanford Professional Fulfillment Index, and 23 (64%) agreed to participate. Themes from the qualitative interviews highlighted the importance of personal lifestyle choices, approaches to improve professional satisfaction, and strategies to foster work‐life harmony. Personal lifestyle strategies included investing in wellness and mental health. Efforts to improve professional satisfaction included decreasing work intensity, prioritizing meaningful aspects of work, and building relationships with colleagues. Fostering work‐life harmony also included making trade‐offs in both domains, setting boundaries at work, setting expectations at home, and overcoming personal challenges. Conclusion Our findings illustrate that, in addition to organizational strategies demonstrated to be effective, there are actions that individual physiatrists can take to recover from burnout and foster professional fulfillment.
Occupational Characteristics Associated with Professional Fulfillment and Burnout Among U.S. Physiatrists
Trockel, Mickey , Kinney, Carolyn L. , Sliwa, James A. , Knowlton, Tiffany, Stautzenbach, Tom, Shanafelt, Tait D. , Makowski, Maryam S , Verduzco-Gutierrez, Monica , Kinney, Carolyn , Sliwa, James , Shanafelt, Tait D , Paganoni, Sabrina , Weinstein, Stuart L. , Verduzco‐Gutierrez, Monica , Kennedy, David J. , Wang, Hanhan

Mayo Clinic

PM&R | February 16, 2023 | Volume: 15 | Issue: 5 | Pages: 541-551

10.1002/pmrj.12961 | PMID 36794660 Get It

AbstractIntroductionMultiple national studies suggest that, among physicians, physiatrists are at increased risk for occupational burnout.ObjectiveTo identify characteristics of the work environment associated with professional fulfillment and burnout among U.S. physiatrists.DesignBetween May and December 2021, a mixed qualitative and quantitative approach was used to identify factors contributing to professional fulfillment and burnout in physiatrists.SettingOnline interviews, focus groups, and survey.ParticipantsPhysiatrists in the AAPM&R Membership Masterfile.Main Outcome MeasuresBurnout and professional fulfillment assessed using the Stanford Professional Fulfillment Index.ResultsIndividual interviews with 21 physiatrists were conducted to identify domains that contributed to professional fulfillment followed by focus groups for further definition. Based on themes identified, scales were identified or developed to evaluate: control over schedule (6 items; Cronbach's alpha = 0.86); integration of physiatry into patient care (3 items; Cronbach's alpha = 0.71); personal‐organizational values alignment (3 items; Cronbach's alpha = 0.90); meaningfulness of physiatrist clinical work (6 items; Cronbach's alpha = 0.90); teamwork and collaboration (3 items; Cronbach's alpha = 0.89). Of 5760 physiatrists contacted in the subsequent national survey, 882 (15.4%) returned surveys (median age 52 years; 46.1% women). Overall, 42.6% (336 of 788) experienced burnout and 30.6% (244 of 798) had high levels of professional fulfillment. In multivariable analysis, each one‐point improvement in control over schedule (odds ratio [OR] = 1.96; 95% confidence interval [CI] = 1.45–2.69), integration of physiatry into patient care (OR = 1.77; 95% CI = 1.32–2.38), personal‐organizational values alignment (OR = 1.92; 95% CI = 1.48–2.52), meaningfulness of physiatrist clinical work (OR = 2.79; 95% CI = 1.71–4.71) and teamwork and collaboration score (OR = 2.11; 95% CI = 1.48–3.03) was independently associated with higher likelihood of professional fulfillment.ConclusionsControl over schedule, optimal integration of physiatry into clinical care, personal‐organizational values alignment, teamwork, and meaningfulness of physiatrist clinical work are strong and independent drivers of occupational well‐being in U.S. physiatrists. Variation in these domains by practice setting and subspecialty suggests tailored approaches are needed to promote professional fulfillment and reduce burnout among U.S. physiatrists.
Burnout in Diplomates of the American Board of Physical Medicine and Rehabilitation—Prevalence and Potential Drivers: A Prospective Cross‐Sectional Survey
Sliwa, James A. , Clark, Gary S., Chiodo, Anthony E., Kinney, Carolyn L. , Raddatz, Mikaela M. , Micheo, William , Robinson, Lawrence R. , Robinson, Lawrence R , Kinney, Carolyn , Francisco, Gerard E.

Mayo Clinic

PM&R | August 31, 2022 | Volume: 11 | Issue: 1 | Pages: 83-89

10.1016/j.pmrj.2018.07.013 | PMID 30703291 Get It

Background Physician burnout is of growing concern. Burnout among physical medicine and rehabilitation (PM&R) physicians has shown a significant increase, positioning PM&R as one of the most “burned out” of specialties. Little has been written about potential factors contributing to physiatrist burnout or potential interventions. Objective To determine the prevalence of burnout among physiatrists and identify risk factors for burnout and potential strategies to decrease burnout among physiatrists. Design Prospective cross‐sectional survey. Setting National survey of board certified physiatrists. Participants: One thousand five hundred thirty‐six physiatrists certified by the American Board of PM&R. Outcome The Mini‐Z Burnout Survey, 1 question from the Maslach Burnout Scale on callousness toward patients, and several potential drivers of burnout. The probability of burnout, identified by question 3 on the Mini‐Z, was the dependent variable. Other questions on the Mini‐Z were explored as independent variables using logistic regression. Results Seven hundred seventy physiatrists (50.7%) fulfilled the definition of burnout. Only 38% of physiatrists reported not becoming more callous toward patients. The top 3 causes of burnout identified by physiatrists were increasing regulatory demands, workload and job demands, and practice inefficiency and lack of resources. Higher burnout rate was associated with high levels of job stress and working more hours per week. Lower burnout rates were associated with higher job satisfaction, control over workload, professional values aligned with those of department leaders, and sufficient time for documentation. There was no significant association between burnout and sex, years in practice, practice focus, or practice area. Conclusion Burnout is a significant problem among PM&R physicians and is pervasive throughout the specialty. Opportunities exist to address major contributing drivers of burnout relating to practice patterns and efficiency of care within PM&R. These opportunities are, to varying degrees, under the control of hospital leaders, practice administrators, and practitioners.
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017
Yadgir, Simon , Johnson, Catherine O., Aboyans, Victor, Adebayo, Oladimeji , Adedoyin, Rufus Adesoji , Afarideh, Mohsen , Alahdab, Fares , Alashi, Alaa , Alipour, Vahid, Arabloo, Jalal , Azari, Samad , Barthelemy, Celine M, Benziger, Catherine P. , Bijani, Ali , Carvalho, Félix , Durães, André Rodrigues , Esteghamati, Alireza , Farid, Talha, Farzadfar, Farshad , Fernandes, Eduarda , Gad, Mohamed M. , Hay, Simon I , Irvani, Seyed Sina Naghibi , Jürisson, Mikk , Kasaeian, Amir , Kengne, André Pascal , Khan, Abdur Rahman , Kısa, Adnan , Manafi, Navid , Manafi, Amir , Мirrakhimov, Erkin М , Mohammad, Yousef , Mokdad, Ali H. , Negoi, Ruxandra Irina , Nixon, Molly R, Patel, Shanti, Pilgrim, Thomas , Rawaf, David Laith , Rawasia, Wasiq Faraz , Rezapour, Aziz , Roever, Leonardo , Saadatagah, Seyedmohammad , Senthilkumaran, Subramanian , Sliwa, Karen, Tesfay, Berhe Etsay , Ullah, Irfan , Roth, Gregory A. , Collaborators, For the Global Burden of Disease Study 2017 Nonrheumatic Valve Disease, Sliwa, Karen , Farzadfar, Farshad , Benziger, Catherine P , Sliwa, K , Pilgrim, Thomas , Aboyans, Victor , Berman, Adam E. , Carrero, Juan Jesús , Daryani, Ahmad , Filip, Irina , Hamidi, Samer , Ilesanmi, Olayinka Stephen , Kısa, Sezer , Kolte, Dhaval , Mensah, George A. , Nguyen, Huong Lan Thi , Nguyen, Trang Huyen , Otto, Catherine M , Radfar, Amir , Rawaf, Salman , Saad, Anas M. , Tran, Bach Xuan , Vaduganathan, Muthiah , Vasankari, Tommi Juhani , Wolfe, Charles D.A. , Yonemoto, Naohiro , Collaborators, For the Global Burden of Disease Study 2017 Nonrheumatic Valve Disease, Alahdab, Fares

Mayo Clinic

Circulation | March 29, 2020 | Volume: 141 | Issue: 21 | Pages: 1670-1680

10.1161/circulationaha.119.043391 | PMID 32223336 Get It

Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700–107 900) and 35 700 (95% UI, 30 500–42 500) deaths, and 12.6 million (95% UI, 11.4 million–13.8 million) and 18.1 million (95% UI, 17.6 million–18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million–2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%–0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%–117%) and 35% (95% UI, 23%–47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
Allopathic (MD) and Osteopathic (DO) Performance on the American Board of Physical Medicine and Rehabilitation Initial Certifying Examinations
Sliwa, James A. , Raddatz, Mikaela M. , Kinney, Carolyn L. , Clark, Gary S., Kinney, Carolyn , Robinson, Lawrence R.

Mayo Clinic

PM&R | December 28, 2019 | Volume: 12 | Issue: 9 | Pages: 899-903

10.1002/pmrj.12311 | PMID 31883237 Get It

BackgroundOsteopathic physicians (DOs) represent over 30% of residents in allopathic (MD) Accreditation Council for Graduate Medical Education (ACGME) accredited physical medicine and rehabilitation (PM&R) training programs. However, some have questioned the quality of osteopathic medical school training and the graduates of osteopathic medical schools. The performance of osteopathic physicians in allopathic PM&R training programs has not been assessed.ObjectiveTo compare allopathic (MD) and osteopathic (DO) physician performance on American Board of Physical Medicine and Rehabilitation (ABPMR) initial certifying examinations.DesignRetrospective cross‐sectional study.SettingBoard‐eligible PM&R physicians.ParticipantsMDs and DOs who completed an allopathic ACGME‐accredited PM&R residency training program.MethodsMD and DO pass rates and mean scaled scores on the ABPMR initial certifying examinations were compared. MD versus DO degrees and training program 6 years aggregate board pass rates were independent variables.InterventionsNot applicable.Main Outcome MeasureMD and DO pass rates and mean scaled scores on the ABPMR initial certifying examinations.ResultsOf the 2187 physicians who were first‐time ABPMR initial certifying examination takers, there were 1596 MDs (73%) and 591 DOs (27%). No statistically significant difference was found in pass rates between MDs and DOs on Part I (94.9% vs. 93.9%, P = .35) or Part II (87.8% vs. 88%, P = .83) of the ABPMR certifying examination. Analysis of mean scaled scores demonstrated higher MD scores on both Part I ( 526, SD = 31, vs. 516, SD = 67, P = .002) and Part II ( 6.73, SD = .83 vs. 6.62, SD = .77, P = .005), significant only in programs with a 90%‐100% pass rate. These differences, however, were of very small magnitude and likely not meaningful from a clinical or educational perspective.ConclusionThis study did not find meaningful differences in performance on the ABPMR certifying examinations between MDs and DOs.
Should There Be A Part II ABPMR Examination?: A Psychometric Inquiry
Chiodo, Anthony E., Raddatz, Mikaela M. , Driscoll, Sherilyn W. , Sliwa, James A. , Clark, Gary S., Robinson, Lawrence R. , Robinson, Lawrence R

Mayo Clinic

PM&R | February 7, 2019 | Volume: 11 | Issue: 10 | Pages: 1115-1120

10.1002/pmrj.12126 | PMID 30729717 Get It

BackgroundCertification by the American Board of Physical Medicine and Rehabilitation (ABPMR) requires passing both a written multiple choice examination (Part I) and an oral examination (Part II), but it has been unclear whether the two examinations measure the same or different dimensions of knowledge.ObjectiveTo evaluate the concordance between the Part I and Part II examinations for ABPMR initial certification with regard to candidate performance on the examinations and their subsets. Our question is whether the Part II examination provides additional assessment of a candidate beyond what Part I provides.DesignRetrospective psychometric evaluation of deidentified board examination scores.SettingABPMR database of Part I and Part II examination scores.ParticipantsCandidates for the ABPMR Part I and Part II examinations after 2005, with a more detailed analysis of candidates for the Part I examination from 2014 to 2016. Examination scores of candidates who took the Part II examination both before and after the examination was standardized in 2005 were also used for an additional analysis.MethodsCorrelations, simple linear regressions, and principal components analysis.Main Outcome MeasurementsCorrelation coefficients, variance analysis, and unexplained variance in the principal components analysis.ResultsThere is a weak to moderate correlation between performance on the Part I and Part II examinations: r = 0.33, P < .001. There is an additional dimension of assessment that is demonstrated on the Part II examination, with this being primarily in the domains of systems‐based practice and interpersonal communication skills.ConclusionThe Part I and Part II examinations, although with some overlap, contribute different and meaningful components to the overall evaluation of candidates for board certification in PM&R.Level of EvidenceIII.
Impact of Socioeconomic Status, Ethnicity, and Urbanization on Risk Factor Profiles of Cardiovascular Disease in Africa
Sliwa, Karen , Acquah, Letitia, Mocumbi, Ana Olga , Gersh, Bernard J. , Sliwa, K

Mayo Clinic

Circulation | March 21, 2016 | Volume: 133 | Issue: 12 | Pages: 1199-1208

10.1161/circulationaha.114.008730 | PMID 27002082 Get It

Africa is a continent characterized by marked ethnic, sociodemographic, and economic diversity, with profound changes in many regions over the past 2 decades. This diversity has an impact on cardiovascular disease presentation and outcomes. Within Africa and within the individual countries, one can find regions having predominantly communicable diseases such as rheumatic heart disease, tuberculous pericarditis, or cardiomyopathy and others having a marked increase in noncommunicable disease such as hypertension and hypertensive heart disease. Ischemic heart disease remains rare in most countries. Difficulties in the planning and implementation of effective health care in most African countries are compounded by a paucity of studies and a low rate of investment in research and data acquisition. The fiduciary responsibilities of companies working in Africa should include the effective and efficient use of natural resources to promote the overall health of populations.
Melatonin as a preventive and curative therapy against pulmonary hypertension
Maarman, Gerald J. , Thienemann, Friedrich , Blauwet, Lori A., Butrous, Ghazwan , Davies, Neil H. , Lecour, Sandrine , Blauwet, Lori, Blackhurst, Dee , Sliwa, Karen

Mayo Clinic

Journal of Pineal Research | July 22, 2015 | Volume: 59 | Issue: 3 | Pages: 343-353

10.1111/jpi.12263 | PMID 26201290 Get It

AbstractPulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure, which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological mechanisms of PH remain unclear but oxidative stress is believed to contribute to RV dysfunction. Melatonin is a powerful antioxidant and is cardioprotective against ischemia–reperfusion injury and hypertension. Therefore, we hypothesized that a chronic treatment with melatonin, given as a curative or preventive therapy, may confer cardiovascular benefits in PH. PH was induced in Long Evans rats (n ≥ 6 per group), with a single subcutaneous injection of monocrotaline (MCT, 80 mg/kg). Melatonin was given daily in the drinking water, with the treatment starting either on the day of the injection of MCT (dose testing: melatonin 75 ng/L and 6 mg/kg), 14 days after the injection of MCT (curative treatment: 6 mg/kg), or 5 days before the injection (preventive treatment: 6 mg/kg). The development of PH was assessed by measuring RV hypertrophy, RV function, cardiac interstitial fibrosis, and plasma oxidative stress. Compared with controls, MCT‐treated rats displayed RV hypertrophy and dysfunction, increased interstitial fibrosis, and elevated plasma oxidative stress. A chronic melatonin treatment (75 ng/L or 6 mg/kg) reduced RV hypertrophy, improved RV function and reduced plasma oxidative stress. Curative and preventive treatment improved RV functional and plasma oxidative stress parameters and reduced cardiac interstitial fibrosis. Our data demonstrate that melatonin confers cardioprotection in this model of PH. As melatonin is an inexpensive and safe drug, we propose that clinical investigation of the effects of melatonin on RV function in patients with PH should be considered.