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14 citation(s) found for "Alexander, Andrew".

Intermuscular Adipose Tissue And Muscle Function In Adults With And Without Obesity
Reynolds, Jake C., Esser, Tobias, Alexander, Andrew M. , Kunz, Hawley E., Rubio, E., Ortiz‐Correa, Zinnarky K., Ryan, Zachary C. , Arendt, Bonnie K., Passehl, Rachel M., Lanza, Ian R. , Reynolds, Jake C., Kunz, Hawley , Arendt, Bonnie K.

Mayo Clinic

Medicine & Science in Sports & Exercise | September 18, 2026 | Volume: 58 | Issue: 10S | Pages: No page available

10.1249/01.mss.0001262724.21676.4b Get It

Intermuscular adipose tissue in healthy human aging—effects of exercise training and implications to metabolic health
Alexander, Andrew M. , Fitzgibbons, Lucy M., Correa, Zinnarky K Ortiz, Nair, K. Sreekumaran , Kunz, Hawley E , Ortiz Correa, Zinnarky K, Nair, K Sreekumaran , Lanza, Ian R , Kunz, Hawley , Port, John D. , Lanza, Ian R.

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Journal of Applied Physiology | October 20, 2025 | Volume: 139 | Issue: 5 | Pages: 1300-1308

10.1152/japplphysiol.00719.2025 | PMID 41115067 Get It

Intermuscular adipose tissue (IMAT) accumulates in the lower leg musculature of healthy older adults. IMAT was negatively associated with the rate of glucose infusion during a hyperinsulinemic-euglycemic clamp and muscle oxidative capacity. Exercise training decreased IMAT to a greater extent in young compared with older adults. Together these data support the implication that IMAT accumulation is linked with metabolic derangements in older adults but the restorative potential of exercise in older adults needs further evaluation.
Effect Of Exercise Training On Intermuscular Adipose Tissue And Insulin Resistance In Young And Older Adults
Alexander, Andrew M. , Fitzgibbons, Lucy M., Bergan, Natalie, Senefeld, Jonathon W. , Lanza, Ian R.

Mayo Clinic

Medicine & Science in Sports & Exercise | September 16, 2025 | Volume: 57 | Issue: 10S | Pages: 774-775

10.1249/01.mss.0001161584.71826.f6 Get It

Femoroacetabular Impingement: Critical Analysis Review of Current Nonoperative Treatments
Dancy, Malik E. , Oladipo, Victoria , Boadi, Prince , Mercurio, Angela M. , Alexander, Andrew , Hevesi, Mario , Krych, Aaron J. , Okoroha, Kelechi R. , Mercurio, Angela , Alexander, Andrew S , Krych, Aaron J , Hevesi, Mario

Mayo Clinic

JBJS Reviews | April 16, 2025 | Volume: 13 | Issue: 4 | Pages: No page available

10.2106/jbjs.rvw.24.00211 | PMID 40238927 Get It

» Femoroacetabular impingement (FAI) is the premature contact of the femoral head-neck junction with the superior acetabular rim during hip range of motion, which may further damage intra-articular soft tissue structures and lead to the accelerated development of osteoarthritis. » FAI syndrome is diagnosed by a triad of symptoms, clinical signs, and imaging findings, and is a common cause of hip pain in young patients that have a significant impact on patient hip-related function and quality of life. » The treatment of FAI syndrome begins with noninvasive nonoperative modalities such as patient education and supervised exercise-based physical therapy. For recalcitrant symptoms, various injections have been explored for both diagnostic and therapeutic purposes; however, the efficacy of these interventions have generally not been demonstrated outside of the short term » In this article, we examine the available literature regarding the nonoperative treatment of FAI and provide insight into the effectiveness of current treatment modalities.
Determinants of symptom presentation and resolution following concussions in high school sports
Boltz, Adrian J. , Lempke, Landon B. , Rao, Neel , Northam, Weston T. , Collins, Christy L. , Alexander, Andrew , Alexander, Andrew S , Chandran, Avinash S. , Alexander, Andrew S., DiPietro, Loretta

Mayo Clinic

Research in Sports Medicine | October 23, 2024 | Volume: 33 | Issue: 1 | Pages: 72-86

10.1080/15438627.2024.2414972 | PMID 39439229 Get It

Body Checking Injuries in National Collegiate Athletic Association Men's Ice Hockey: Findings From the NCAA Injury Surveillance Program 2009/10 to 2019/20
Boltz, Adrian J. , Garcia, Reagan E., Collins, Christy L. , Alexander, Andrew , Alexander, Andrew S , Alexander, Andrew S., Mihalik, Jason P. , Chandran, Avinash S.

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Clinical Journal of Sport Medicine | July 9, 2024 | Volume: 34 | Issue: 6 | Pages: 583-590

10.1097/jsm.0000000000001255 | PMID 38980686 Get It

Objective: To describe the epidemiology of body checking injuries in the National Collegiate Athletic Association (NCAA) Men's Ice Hockey. Design: Secondary data analysis of historical cohort data. Setting: A convenience sample of injuries in NCAA Men's Ice Hockey during the 2009/10 to 2019/20 academic years. Patients (or Participants) NCAA student-athletes. Independent Variables: Event type, season, time loss, body part, diagnosis, player position, and mechanism. Main Outcome Measures: This study examined injuries that occurred during practice or competition, regardless of time loss, reported to the NCAA Injury Surveillance Program. Injury counts, rates, and proportions were used. The injury rate and proportion ratios with 95% confidence intervals were also constructed. Three independent logistic regression models were constructed to examine differential odds of time loss (≥1 day; TL) injury and the 2 most common injuries, between body checking injuries and all other injuries. Results: Overall, 1290 body checking injuries (rate = 1.59/1000 athlete-exposures) were reported during the study period. Most were attributed to the upper extremity (42%) or head/neck (27%). The competition injury rate generally decreased after 2012/13. After adjusting for covariates, odds of (1) a TL injury was lower and (2) an acromioclavicular sprain was higher among body checking injuries as compared with injuries attributed to all other activities. Odds of concussion was not associated with body checking injuries. Conclusions: Body checking injuries were frequently attributed to the head/neck and upper extremities, and the rate of these injuries during competition appeared to be decreasing. Still, improvements in helmet and shoulder pad technology may further improve health and safety.
No Differences in Exercise Performance, Perceptual Response, or Safety Were Observed Among 3 Blood Flow Restriction Devices
Dancy, Malik E. , Alexander, Andrew , Abbas, Muhammad J. , Rolnick, Nicholas , Alder, Kareme D. , Okoroha, Kelechi R. , Alexander, Andrew S , Lu, Yining

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Arthroscopy, Sports Medicine, and Rehabilitation | November 20, 2023 | Volume: 5 | Issue: 6 | Pages: No page available

10.1016/j.asmr.2023.100822 | PMID 38058769 Get It

Purpose To compare 3 separate blood flow restriction (BFR) systems in their capacity to reduce repetitions to failure, impact perceptual responses, and cause adverse events during a low‐load free‐flow exercise. Methods The study included healthy subjects aged 18 years or older who presented to an ambulatory‐care sports medicine clinic. On day 1, participants’ demographic characteristics and anthropomorphic measurements were recorded. Each participant performed dumbbell biceps curl repetitions to failure using 20% of his or her 1‐repetition maximum weight with each arm. Participants were exposed to 3 different tourniquet systems for familiarization. On day 2, each participant’s arm was randomized to a cuff system, and the participant performed 2 sets of biceps curl repetitions to failure with the cuff inflated. Repetitions to failure, rating of perceived effort (RPE), rating of perceived discomfort, and pulse oxygenation levels were recorded after each set. On day 3, participants completed a survey of their perceived delayed‐onset muscle soreness. Results The final analysis was performed on 42 arms, with 14 limbs per system. The study population had a mean age of 28.7 ± 2.4 years and a mean body mass index of 24.9 ± 4.3. All 3 systems successfully reduced repetitions to failure compared with unrestricted low‐load exercise from baseline to BFR set 1 and from baseline to BFR set 2. There were no significant between‐group differences among BFR systems regarding the number of repetitions to failure performed at baseline versus BFR set 1 or BFR set 2. The Delfi Personalized Tourniquet System (PTS) cohort had the greatest reductions in repetitions to failure from BFR set 1 to BFR set 2 ( P = .002) and reported the highest RPE after set 2 ( P = .025). Conclusions The Delfi PTS, SmartCuffs Pro, and BStrong BFR systems were each safe and were able to significantly reduce repetitions to failure compared with a low‐load free‐flow condition when used in a BFR exercise protocol. The Delfi PTS system may produce a higher RPE with prolonged use in comparison to the other systems. Level of Evidence Level II, prospective cohort study.
Gluteal Tendinopathy
Dancy, Malik E. , Alexander, Andrew , Clark, Julian , Marigi, Erick M. , Hevesi, Mario , Levy, Bruce A. , Krych, Aaron J. , Okoroha, Kelechi R. , Alexander, Andrew S , Clark, Clarence Julian , Krych, Aaron J , Marigi, Erick , Hevesi, Mario

Mayo Clinic

JBJS Reviews | October 9, 2023 | Volume: 11 | Issue: 10 | Pages: No page available

10.2106/jbjs.rvw.23.00101 | PMID 37812677 Get It

» Gluteal tendinopathy/greater trochanteric pain syndrome (GTPS) is the most prevalent of all lower limb tendinopathies, affecting 1 in 4 women older than 50 years and commonly individuals within their fifth and sixth decades of life regardless of activity level. » The condition is believed to originate from age-related degenerative changes about the hip abductor tendon insertions and the surrounding bursae, and is exacerbated by congenital and acquired abnormal hip biomechanics. » Treatment of gluteal tendinopathy/GTPS often begins with noninvasive nonoperative modalities such as activity modifications, nonsteroidal anti-inflammatory drugs, and physical therapy. For recalcitrant symptoms, additional nonoperative therapies have been used; however, there remains a lack of comparative efficacy between these adjunct treatments. » In this article, we examine the available literature regarding the nonoperative management of gluteal tendinopathy/GTPS and provide insight into the effectiveness of current treatment modalities.
Determinants Of Symptom Presentation And Resolution Following Concussions In High School Sports
Boltz, Adrian J. , Lempke, Landon B. , Rao, Neel , Northam, Weston T. , Collins, Christy L. , Chandran, Avinash S. , Alexander, Andrew S., DiPietro, Loretta

Mayo Clinic

Medicine & Science in Sports & Exercise | September 26, 2023 | Volume: 55 | Issue: 9S | Pages: 984-985

10.1249/01.mss.0000989000.69943.c8 Get It

Sex differences in the intensity–duration relationships of the severe‐ and extreme‐intensity exercise domains
Alexander, Andrew M. , Hurla, Logan M., Didier, Kaylin D. , Hammer, Shane M. , Rollins, Korynne S. , Barstow, Thomas J.

Mayo Clinic

European Journal of Sport Science | May 18, 2023 | Volume: 23 | Issue: 11 | Pages: 2221-2231

10.1080/17461391.2023.2215723 | PMID 37199235 Get It

ABSTRACTExtreme‐intensity exercise is described by W′ext (analogous to J′ for isometric exercise) that is smaller than W′ of severe‐intensity exercise (W′sev) in males. Sex differences in exercise tolerance appear to diminish at near‐maximal exercise, however, there is evidence of greater contributions of peripheral fatigue (i.e. potentiated twitch force; Qpot) in males during extreme‐intensity exercise. Therefore, the current study tested the hypotheses that J′ext would not be different between males and females, however, males would exhibit a greater reduction in neuromuscular function (i.e. maximal voluntary contraction, MVC; Qpot) following extreme‐intensity exercise. Seven males and 7 females completed three severe‐ (Tlim: 2–4 min, S3; 5–8 min, S2; 9–15 min, S1) and three extreme‐intensity (70, 80, 90%MVC) knee‐extension bouts. MVC and Qpot relative to baseline were compared at task failure and at 150 s of recovery. J′ext was significantly less than J′sev in males (2.4 ± 1.2kJ vs 3.9 ± 1.3kJ; p = 0.03) and females (1.6 ± 0.8kJ vs 2.9 ± 1.7kJ; p = 0.05); however, there were no sex differences in J′ext or J′sev. MVC (%Baseline) was greater at task failure following extreme‐intensity exercise (76.5 ± 20.0% vs 51.5 ± 11.5% in males, 75.7 ± 19.4% vs 66.7 ± 17.4% in females), but was not different at 150 s of recovery (95.7 ± 11.8% in males, 91.1 ± 14.2% in females). Reduction in Qpot, however, was greater in males (51.9 ± 16.3% vs 60.6 ± 15.5%) and was significantly correlated with J′ext (r2 = 0.90, p < 0.001). Although there were no differences in the magnitude of J′ext, differences in MVC and Qpot are evidence of sex‐specific responses and highlight the importance of appropriately characterizing exercise intensity regarding exercise domains when comparing physiological responses in males and females.Highlights We have previously shown evidence that extreme‐intensity dynamic exercise is described by W′ext in males and smaller than W′sev. We currently tested for potential sex differences in J′ext (isometric analogue to W′) and neuromuscular responses (i.e. maximal voluntary contraction, MVC; potentiated twitch force, Qpot) during extreme‐intensity exercise. J′ext and extreme‐intensity exercise tolerance was not different between males and females. The reduction in MVC was not different across extreme‐intensity exercise across males and females, whereas the reduction in Qpot was greater in males following all extreme‐intensity exercises, although not after exercise at 90%MVC. Together, although extreme‐intensity exercise tolerance is not different, these data highlight differences in the contributing mechanisms of fatigue during severe‐ and extreme‐intensity exercise between males and females.