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98 citation(s) found for "Sebastian, Arjun".

Anterior Cervical Osteophyte Resection for Treatment of Dysphagia
Kolz, Joshua M. , Alvi, Mohammed Ali , Bhatti, Atiq R., Tomov, Marko , Bydon, Mohamad , Sebastian, Arjun S. , Elder, Benjamin D. , Fogelson, Jeremy L. , Currier, Bradford L. , Freedman, Brett A. , Alvi, Mohammed A, Tomov, Marko N., Freedman, Brett A , Alvi, Mohammed Ali , Nassr, Ahmad

Mayo Clinic

Global Spine Journal | March 20, 2020 | Volume: 11 | Issue: 4 | Pages: 488-499

10.1177/2192568220912706 | PMID 32779946 Get It

Study Design: This was a retrospective cohort study. Objectives: When anterior cervical osteophytes become large enough, they may cause dysphagia. There is a paucity of work examining outcomes and complications of anterior cervical osteophyte resection for dysphagia. Methods: Retrospective review identified 19 patients who underwent anterior cervical osteophyte resection for a diagnosis of dysphagia. The mean age was 71 years and follow-up, 4.7 years. The most common level operated on was C3-C4 (13, 69%). Results: Following anterior cervical osteophyte resection, 79% of patients had improvement in dysphagia. Five patients underwent cervical fusion; there were no episodes of delayed or iatrogenic instability requiring fusion. Fusion patients were younger (64 vs 71 years, P = .05) and had longer operative times (315 vs 121 minutes, P = .01). Age of 75 years or less trended toward improvement in dysphagia ( P = .09; OR = 18.8; 95% CI 0.7-478.0), whereas severe dysphagia trended toward increased complications ( P = .07; OR = 11.3; 95% CI = 0.8-158.5). Body mass index, use of an exposure surgeon, diffuse idiopathic skeletal hyperostosis diagnosis, surgery at 3 or more levels, prior neck surgery, and fusion were not predictive of improvement or complication. Conclusions: Anterior cervical osteophyte resection improves swallowing function in the majority of patients with symptomatic osteophytes. Spinal fusion can be added to address stenosis and other underlying cervical disease and help prevent osteophyte recurrence, whereas intraoperative navigation can be used to ensure complete osteophyte resection without breaching the cortex or entering the disc space. Because of the relatively high complication rate, patients should undergo thorough multidisciplinary workup with swallow evaluation to confirm that anterior cervical osteophytes are the primary cause of dysphagia prior to surgery.
What Is the Optimal Surgical Treatment for Low-Grade Isthmic Spondylolisthesis? ALIF or TLIF?
Sebastian, Arjun S. , Dalton, David , Slaven, Sean E. , Welch-Phillips, Adanna, Fredericks, Donald R. , Ahern, Daniel P. , Butler, Joseph S.

Mayo Clinic

Clinical Spine Surgery: A Spine Publication | January 16, 2020 | Volume: 33 | Issue: 10 | Pages: 389-392

10.1097/bsd.0000000000000926 | PMID 33000930 Get It

A Comparison of Revision Rates and Patient-Reported Outcomes for a 2-Level Posterolateral Fusion Augmented With Single Versus 2-Level Transforaminal Lumbar Interbody Fusion
Kaye, I. David , Fang, Terry, Wagner, Scott C. , Butler, Joseph S. , Sebastian, Arjun S. , Morrissey, Patrick B. , Levine, Marc J., Vaccaro, Alexander R. , Hilibrand, Alan S. , Sebastian, Arjun, Vaccaro, Alex R , Fang, Terry, Levine, Marc J.

Mayo Clinic

Global Spine Journal | November 20, 2019 | Volume: 10 | Issue: 8 | Pages: 958-963

10.1177/2192568219889360 | PMID 32875833 Get It

Study Design: Retrospective, single institution, multisurgeon case control series. Objective: To determine whether there are differences in reoperation rates or outcomes for patients undergoing 2-level posterolateral fusion (PLF) augmented by a transforaminal lumbar interbody fusion (TLIF) at only one of the levels or at both. Methods: A total of 416 patients were identified who underwent 2-level PLF with a TLIF at either one of those levels (n = 183) or at both (n = 233) with greater than 1-year follow-up. Demographic, surgical, radiographic, and clinical data was reviewed for each patient. These included age, sex, race, body mass index, smoking status, Charleston Comorbidity Index, operative time, estimated blood loss, length of stay, and patient-reported outcome measures. Results: Each cohort underwent 24 reoperations. Although the number of overall reoperations was not significantly different ( P > .05), among the reoperation types, there were significantly more reoperations for adjacent segment disease in the 2-level group compared to the 1-level group (19 vs 12, P = .04). There was no difference in reoperation for pseudarthrosis between the groups ( P > .05). Although both groups experienced significant improvements in Oswestry Disability Index ( P < .001) and Short Form–12 health questionnaire ( P < .001), there were no differences between improvements for 1- versus 2-level cohorts. Conclusions: For patients undergoing 2-level PLF in the setting of a TLIF, using a TLIF at one versus both levels does not seem to influence reoperation rates or outcomes. However, reoperation rates for adjacent segment disease are increased in the setting of a 2-level PLF augmented by a 2-level TLIF.
Teriparatide treatment increases Hounsfield units in the lumbar spine out of proportion to DEXA changes
Mikula, Anthony L. , Puffer, Ross C. , Jeor, Jeffery D. St. , Bernatz, James T. , Fogelson, Jeremy L. , Sebastian, Arjun S. , Freedman, Brett A. , Currier, Bradford L. , Bydon, Mohamad , Yaszemski, Michael J. , Anderson, Paul A. , Elder, Benjamin D. , Larson, A. Noelle , Nassr, Ahmad

Mayo Clinic

Journal of Neurosurgery: Spine | October 19, 2019 | Volume: 32 | Issue: 1 | Pages: 50-55

10.3171/2019.7.spine19654 | PMID 31628287 Get It

OBJECTIVEThe authors sought to assess whether Hounsfield units (HU) increase following teriparatide treatment and to compare HU increases with changes in bone mineral density (BMD) as measured by dual-energy x-ray absorptiometry (DEXA).METHODSA retrospective chart review was performed from 1997 to 2018 across all campuses at our institution. The authors identified patients who had been treated with at least 6 months of teriparatide and compared HU and BMD as measured on DEXA scans before and after treatment.RESULTSFifty-two patients were identified for analysis (46 women and 6 men, average age 67 years) who underwent an average of 20.9 ± 6.5 months of teriparatide therapy. The mean ± standard deviation HU increase throughout the lumbar spine (L1–4) was from 109.8 ± 53 to 133.9 ± 61 HU (+22%, 95% CI 1.2–46, p value = 0.039). Based on DEXA results, lumbar spine BMD increased from 0.85 to 0.93 g/cm2 (+9%, p value = 0.044). Lumbar spine T-scores improved from −2.4 ± 1.5 to −1.7 ± 1.5 (p value = 0.03). Average femoral neck T-scores improved from −2.5 ± 1.1 to −2.3 ± 1.0 (p value = 0.31).CONCLUSIONSTeriparatide treatment increased both HU and BMD on DEXA in the lumbar spine, without a change in femoral BMD. The 22% improvement in HU surpassed the 9% improvement determined with DEXA. These results support some surgeons’ subjective sense that intraoperative bone quality following teriparatide treatment is better than indicated by DEXA results. To the authors’ knowledge, this is the first study demonstrating an increase in HU with teriparatide treatment.
Cost of Readmissions Following Anterior Cervical Discectomy and Fusion: Insights from the Nationwide Readmissions Database
Bhandarkar, Archis R. , Alvi, Mohammed Ali , Kerezoudis, Panagiotis , Yolcu, Yagiz U. , Habermann, Elizabeth B. , Sebastian, Arjun S. , Bydon, Mohamad , Habermann, Elizabeth , Alvi, Mohammed Ali , Goyal, Anshit

Mayo Clinic

Neurosurgery | September 26, 2019 | Volume: 87 | Issue: 4 | Pages: 679-688

10.1093/neuros/nyz443 | PMID 31642499 Get It

Abstract BACKGROUND Postoperative readmissions are a significant driver of variation in bundled care costs associated with cervical spine surgery. OBJECTIVE To determine the factors predicting the cost of readmission episodes following elective anterior cervical discectomy and fusion (ACDF). METHODS We queried the Healthcare Cost and Utilization Project Nationwide Readmissions Database for patients undergoing elective ACDF during 2012 to 2015. Multivariable linear regression was performed to establish the factors associated with the cost of each 30-/90-d readmission episode. RESULTS A total of 139 877 and 113 418 patients met inclusion criteria for the evaluation of 30- and 90-d readmissions, respectively. Among these, the national rates of 30- and 90-d readmission after an elective ACDF were 3% and 6%, respectively. The median cost of a 30- and 90-d readmission episode was $6727 (IQR: $3844-$13 529) and $8507 (IQR: $4567-$17 460), respectively. Relative predictor importance analysis revealed that the number of procedures at index admission (IA), length of stay at IA, and time elapsed between index surgical admission and readmission were the top predictors of both 30- and 90-d readmission costs (all P < .001). Although cervical myelopathy accounted for only 3.6% of all 30-d readmissions, it accounted for the largest share (8%) of 30-d readmission costs. CONCLUSION In this analysis from a national all-payer database, we determined the factors associated with the cost of readmissions following elective ACDF. These results are important in assisting policymakers and payers with a better risk adjustment in bundled care payment systems and for surgeons in implementing readmission cost-reduction efforts.
A Review and Clinical Perspective of the Impact of Osteoporosis on the Spine
Carlson, Bayard C. , Robinson, William A. , Wanderman, Nathan , Sebastian, Arjun S. , Freedman, Brett A. , Anderson, Paul A. , Wanderman, Nathan R, Freedman, Brett A , Nassr, Ahmad

Mayo Clinic

Geriatric Orthopaedic Surgery & Rehabilitation | July 17, 2019 | Volume: 10 | Issue: No issue available | Pages: No page available

10.1177/2151459319861591 | PMID 31360592 Get It

Introduction: Osteopenia and osteoporosis are common conditions in the United States. The health consequences of low bone density can be dire, from poor surgical outcomes to increased mortality rates following a fracture. Significance: This article highlights the impact low bone density has on spine health in terms of vertebral fragility fractures and its adverse effects on elective spine surgery. It also reviews the clinical importance of bone health assessment and optimization. Results: Vertebral fractures are the most common fragility fractures with significant consequences related to patient morbidity and mortality. Additionally, a vertebral fracture is the best predictor of a subsequent fracture. These fractures constitute sentinel events in osteoporosis that require further evaluation and treatment of the patient’s underlying bone disease. In addition to fractures, osteopenia and osteoporosis have deleterious effects on elective spine surgery from screw pullout to fusion rates. Adequate evaluation and treatment of a patient’s underlying bone disease in these situations have been shown to improve patient outcomes. Conclusion: With an increased understanding of the prevalence of low bone mass and its consequences as well an understanding of how to identify these patients and appropriately intervene, spine surgeons can effectively decrease the rates of adverse health outcomes related to low bone mass.
Bullet Cage Versus Crescent Cage Design in Transforaminal Lumbar Interbody Fusion
Wanderman, Nathan , Sebastian, Arjun S. , Fredericks, Donald R. , Slaven, Sean E. , Helgeson, Melvin D. , Sebastian, Arjun

Mayo Clinic

Clinical Spine Surgery: A Spine Publication | March 7, 2019 | Volume: 33 | Issue: 2 | Pages: 47-49

10.1097/bsd.0000000000000814 | PMID 30844859 Get It

Effect of teriparatide use on bone mineral density and spinal fusion: a narrative review of animal models
Yolcu, Yagiz U. , Alvi, Mohammed Ali , Wanderman, Nathan , Carlson, Bayard C. , Sebastian, Arjun S. , Bydon, Mohamad , Freedman, Brett A. , Yolcu, Yagiz, Alvi, Mohammed, Carlson, Bayard, Sebastian, Arjun, Alvi, Mohammed Ali

Mayo Clinic

International Journal of Neuroscience | December 27, 2018 | Volume: 129 | Issue: 8 | Pages: 814-820

10.1080/00207454.2018.1564051 | PMID 30587048 Get It

Decompression With or Without Fusion for Adjacent Segment Disease Without Instability
Wanderman, Nathan , Geletta, Mattew, Sharma, Rishi , Sebastian, Arjun S. , Kaye, David , Sebastian, Arjun

Mayo Clinic

Clinical Spine Surgery: A Spine Publication | November 20, 2018 | Volume: 32 | Issue: 5 | Pages: 179-181

10.1097/bsd.0000000000000750 | PMID 30475242 Get It

Does Surgically Managed Grade I Degenerative Lumbar Spondylolisthesis Require Fusion?
Pisano, Alfred J. , Butler, Joseph S. , Sebastian, Arjun S. , Wagner, Scott C. , Wanderman, Nathan , Sebastian, Arjun

Mayo Clinic

Clinical Spine Surgery: A Spine Publication | July 3, 2018 | Volume: 32 | Issue: 4 | Pages: 133-136

10.1097/bsd.0000000000000684 | PMID 29975202 Get It