Citations

Thyroid cancer is the fastest growing age and gender adjusted cancer in 2011 according the American Cancer Society. The majority of the clinically diagnosed thyroid nodules are benign while less than 5% represent intrathyroidal cancers. Currently, the clinical gold-standard procedure for assessing the thyroid nodules is needle biopsy, a procedure that is associated with significant financial burden as well as pain and risk for patients. Therefore, a noninvasive, affordable, and potentially widely available method to differentiate between benign and malignant thyroid nodules can play an important role in reducing the number of unnecessary biopsies. In this study, we investigate the feasibility of two acoustic radiation force elastography techniques, shear wave dispersion ultrasound vibrometry (SDUV) and comb-push ultrasound shear wave elastography (CUSE imaging), in identifying thyroid nodules (imaging) and differentiating between benign and malignant pathologies based on their elasticity and viscosity (SDUV measurements). Our preliminary results show that the measured shear elasticity and shear viscosity parameters depend on tissue type; hence, these measurements may be utilized to differentiate between healthy normal thyroid tissue, benign nodules, and malignant nodules. Further studies on a large population of patients is required to better evaluate the role of the combination of elasticity and viscosity properties of tissue in differentiating various thyroid nodules.

The surface roughness (of about 20 microns) of an acrylic block immersed in water was measured using the acoustic emission pressure field (in the kHz range) induced by the dynamic radiation force of ultrasound (2 MHz). The dynamic radiation force is produced by mixing two beams of different frequencies to excite the probed object. The acoustic emission is a result of object vibration at the difference frequency of the incident ultrasound beams and is detected by a low-frequency hydrophone placed nearby the block. Due to the presence of the block, an ultrasound standing wave field is generated as a result of multiple reflections between the transducer and the block’s surface. The acoustic emission by the block’s surface varies according to its relative position to the transducer. This variation is used to form an image of the surface roughness at two difference frequencies Δf=9.9 and 22.4 kHz. To have a one-to-one map between the surface roughness and the image, the surface variation has to lie within the distance from a maximum to its nearest minimum in the standing wave. Images obtained here demonstrate that vibroacoustography may be used as a powerful tool for the nondestructive inspection and imaging of surface roughness [Mitri et al., Appl. Phys. Lett. 88, 234105 (2006)]. [Work supported by NIH.]

Vibro-acoustography image is a function of the dynamic characteristics of the object at the vibration (difference) frequency (df). The dynamic characteristic of tissue is closely related to pathology. Therefore, it is important to evaluate image features versus df. Here, the influence of df on breast vibro-acoustography images is studied by scanning human breast at various df values ranging from 20 to 90 kHz. The subjects were chosen from a group of volunteers with different breast abnormalities. Images were compared subjectively to study image features and the appearances of breast lesions versus df. It is demonstrated that having a collection of images of the same tissue at different df values generally provides a better perception of the tissue structure and improves lesion identification. In most cases, higher df resulted in a higher signal-to-noise ratio and thus a higher image quality. Finally, a frequency-compounded images was obtained by calculating the weighted sum of images at different df values. It is demonstrated that image compounding normally improves visualization of breast tissue and abnormalities. [Work supported by NIH Grant EB-00535 and Grant BCTR0504550 from the Susan G. Komen Breast Cancer Foundation. Disclosure: Parts of the techniques used here are patented by MF and JFG.]

Shear wave dispersion ultrasound vibrometry (SDUV) has been introduced to use the dispersive nature of shear wave speed to locally estimate the material properties or tissue. Shear waves were created using a mechanical shaker and pulsed radiation force. Using the information from the phase one can estimate the shear velocity. A theoretical Voigt model allows us to find, at different frequencies (100–400 Hz), the viscosity and shear elasticity of the polymer gel dosimeter. The aim of this work was to perform the SDUV and mechanical vibrometry techniques to study the viscoelastic properties of absorbed dose phantoms. The experiments were performed using five phantoms of different absorbed doses varying 10 up to 50 Gy, while a nonirradiated phantom was kept as a control. The SDUV technique was performed using a pulsed radiation force to vibrate the gel provide by a confocal transducer with a focal depth of 70 mm, nominal frequency of 3 MHz. For the mechanical vibrometry and SDUV experiments, shear wave motion measurements were made with a commercial ultrasound machine with a research using a 10 MHz linear array transducer. The quantitative elasticity and viscosity results for these two experiments were compared.

This work introduces a new method based on acoustic radiation force and magnetic measurement for interrogating the mechanical properties of fluid and biological tissues. In this method, ultrasound radiation is used to exert a low-frequency (in kHz range) force on a rigid magnetized target immersed in a viscoelastic medium. In response, the target vibrates in a pattern determined by viscoelastic properties of medium. We report the relation between the magnetic field signal and the incident ultrasonic pressure field in terms of the mechanical parameters of the medium. Simulations were conducted to demonstrate a simple approach based on using amplitude-modulated ultrasound to generate a dynamic acoustic radiation force on a magnetic target. The magnetic field generated by vibration of this target is then obtained and used to estimate the radiation-force-induced displacement as a function of time. It was observed that the intensity of the dynamic component of the magnetic field caused by the acoustic excitation is high enough to be registered by a conventional magnetic sensor. This proposed methodology presents a powerful tool for evaluation of acoustic radiation force as well as the mechanical properties of soft material.

Measurement of surface roughness irregularities is an important indicator of product quality for many nondestructive testing industries. Many techniques exist; however, because of their qualitative, time-consuming and direct-contact modes, it is of some importance to work out new experimental methods and efficient tools for quantitative estimation of surface roughness. Continuous-wave ultrasound reflectometry (CWUR) is presented here as a novel nondestructive modality for imaging and measuring surface roughness in a noncontact mode. In CWUR, voltage variations due to phase shifts in the reflected ultrasound waves are recorded and processed to form an image of surface roughness. An acrylic test block with surface irregularities ranging from 4.22 to 19.05 μm as measured by a coordinate measuring machine (CMM) is scanned by an ultrasound transducer having a diameter of 45 mm, a focal distance of 70 mm, and a central frequency of 3 MHz. It is shown that CWUR technique gives very good agreement with the results obtained through CMM inasmuch as the maximum average percent error is around 11.5%.

The mechanical response of tissues to external forces has gained considerable interest in medical diagnosis. One approach of imaging the tissue elastic properties is to apply an external force on the surface of the body. Another approach is to generate a localized force inside the tissue with the radiation force of ultrasound. In this paper, a noninvasive method for imaging the vibration mode of an object is investigated. The radiation force of ultrasound is used to scan the object at a resonant frequency of the object. The vibration of the object is measured by laser and the resulting acoustic emission from the object is measured by a hydrophone. Experimental studies are carried out on a mechanical heart valve and arterial phantoms. The mode images on the valve are made by the hydrophone measurement and confirmed by FEM simulations. Compared with conventional B-scan imaging on arterial phantoms, the mode imaging can show not only the interface of the artery and the gelatin, but also the vibration modes of the artery. The images taken on the phantom surface suggest that an image of an interior artery can be made by vibration measurements on the surface of the body.

Vibro-acoustography is an imaging method based on the sound emitted due to the harmonic motion of tissue induced by the radiation force of focused ultrasound. This paper presents recent progress in vibro-acoustography of human breast. Matching vibro-acoustography and mammography images are acquired using a combined mammography/vibro-acoustography machine. Images of various types of breast masses are investigated and their characteristics features are compared. The study includes malignant masses, benign masses such as fibroadenomas, cysts, calcified lesions, and surgical scars. Image features, such as lesion borders, interior texture, and speculation pattern, are studied. Vibro-acoustography images demonstrate that calcified masses normally show sharp borders, benign noncalcified masses have smooth texture, and, in some cases, malignant masses are characterized with spiculation. These results, which are based on the data collected from an ongoing study, indicate that the above-mentioned image features may be used for differentiation of breast masses. It is noted that more data from a larger population are needed to establish the results in a statistical sense. [Work supported by NIH Grant EB-00535 and Grant BCTR0504550 from the Susan G. Komen Breast Cancer Foundation. Disclosure: Parts of the techniques used here are patented by MF and JFG.]

The ultrasound radiation force can be used as a noncontact method for exciting vibrational modes. In one implementation, an audio-range modulation signal is combined with a 40-kHz carrier to form a double-sideband suppressed-carrier (DSSC) waveform that is emitted from an ultrasound transducer. The frequency of the ultrasound radiation force is the difference between the frequencies of the sidebands, therefore at twice the modulation frequency. We describe a method for selective mode excitation using a transducer pair, each emitting a DSSC signal. The modulation signal for one transducer was phase shifted relative to the other transducer. When the two modulation signals were in phase, the radiation stress field was uniform. For devices studied, this excited transverse modes while suppressing torsional modes. Similarly, if the modulation signals were out of phase, torsional modes were excited while suppressing transverse modes. This technique has been demonstrated for devices including an MEMS mirror, hard-drive suspension, and brass cantilever. For a cantilever, the ratio of the amplitudes of 180-Hz transverse over 1.3-kHz torsional modes was varied by over two orders of magnitude by shifting the phase difference between the two beams over a range of 90 deg. This noncontact technique allows control over the types of vibration excited.

Vibro-acoustography is a method that uses the dynamic radiation force (stress) of ultrasound to locally excite an object at low frequency [Fatemi and Greenleaf, Science 280, 82]. A multifrequency vibro-acoustography method is proposed that uses a multifrequency radiation stress produced by an array transducer driven with N ultrasound frequencies. A multifrequency image at the different N(N−1)/2 frequencies is produced with one scan of the region of interest, increasing the information yield by a factor of N(N−1)/2. Image formation theory is presented for multifrequency vibro-acoustography using an annular array transducer. Simulations of the stress field were performed for a 20-element, 3.5-MHz annular array transducer. Four ultrasound frequencies produce six unique low-frequency components in the point spread function. Computer phantoms with small spheres are used to demonstrate the usefulness of multifrequency vibro-acoustography for microcalcification detection in breast imaging. The lateral and axial width of the main lobe at −6 dB is 0.68 and 6.47 mm, respectively. The lateral and axial sidelobe levels are −27.8 and −16.8 dB, respectively. The proposed method holds the potential for large gains of information with good spatial resolution and no increase in scanning time. [Work supported by Grant EB00535-03 from NIH.]