Citations

Harmonic or pulsed radiation pressure and subsequent measurement of the tissue response can be used to accurately quantitatively measure fundamental material properties of tissue. The measurement of shear wave dispersion can be used to estimate elastic shear moduli of tissue using an appropriate model. Fundamental model free properties such as complex modulus can also be measured. Ultrasound radiation pressure is used to induce free propagating shear waves. The measurable properties of the shear waves such as speed are sensitive to only the local material properties of the tissue under certain circumstances. A model relating the shear wave speed as a function of frequency is related to the elastic and viscous moduli within small regions of tissue according to, for instance, the Voigt model. Shear and elastic moduli in tissue are measured with high accuracy and precision given appropriate models of wave propagation within the geometry of the tissue. Complex modulus in liver of live pig and other tissues have been made. Careful use of shear wave propagation and subsequent measurements can provide fundamental quantitative measurements of tissue mechanical properties if models are accurate. An application of this method is the noninvasive measurement of liver stiffness as a surrogate for fibrosis.

Arterial wall stiffness can be associated with various diseases. The stiffness of an artery can be assessed by measurement of the pulse wave velocity (PWV). Usually, PWV is estimated using the foot-to-foot method. However, the foot of the pressure wave is not very clear due to reflected waves. Also, the blood pressure wave generated by the heart is normally a low frequency wave, hence the time resolution is low. PWV is an average indicator of artery stiffness between two measuring locations, therefore, it is not easy to identify local stiffness. In this paper a short external pulse is generated in an artery by the radiation force of ultrasound. The propagation velocity of the pulse wave is measured along the artery. The temporal resolution of this method, which is in the range of microseconds, is much higher than the conventional pressure PWV method, and therefore allows the wave velocity to be measured accurately over a few millimeters.

In paper, we report our recent results of using the air force ultrasound transducer to study the resonance of rubber tubes. Experiments were carried out on a rubber latex tube. Seven resonant frequencies were measured between 50 Hz and 200 Hz. Theoretical calculation of the resonant frequency on the tube was done with the wave propagation approach. The relative differences of the seven resonant frequencies between the experiment and the theory are less than 6 %. This research shows that the air force ultrasound transducer can be used for tube resonance measurement.

The mechanical response of tissues to external forces has gained considerable interest in medical diagnosis. One approach to imaging tissue elastic properties is to apply an external force on the surface of the body. Another approach is to generate a localized force inside the tissue with the radiation force of ultrasound. In this paper, a new method is developed to estimate tissue’s elasticity based on surface wave speed measurement. The theory of surface wave speed is developed for estimating tissue’s elasticity. Experiments are carried out on a tissue-mimicking ultrasound phantom. An amplitude modulated ultrasound signal of a few hundred hertz is used to generate a localized force in the phantom. The surface wave fields are measured with a laser vibrometer. It shows that the surface wave speed can be used for inversely estimating tissue’s elastic properties based on tissue’s surface measurement.

Arterial wall stiffness can be associated with various diseases. Arteriosclerosis involves the buildup of plaques within artery walls that stiffen the arteries. The stiffness of an artery can be assessed by measurement of the pulse wave velocity (PWV). Usually, PWV is estimated using the foot-to-foot method. However, the foot of the pressure wave is not very clear due to reflected waves. Also, the blood pressure wave generated by the heart is normally a low frequency wave, hence the time resolution is low. PWV is an average indicator of artery stiffness between the two measuring positions, and therefore cannot easily identify local stiffness. In this paper a force on the arterial wall is generated noninvasively by the radiation force of ultrasound. Techniques for measuring the propagating wave due to this localized force are studied. The excitation force can be either a very short pulse or a modulated cw signal of a few hundred hertz. The temporal resolution of this method, which is in the range of microseconds, is much higher than the conventional pressure PWV method, and therefore allows the wave velocity to be measured accurately over short distances of a few millimeters.

The inverse problem of determining the size, shape and orientation of a submerged object using the scattered field data is studied. Based on the physical optics approximate, the profile function of the object is found directly proportional to its ramp response that is the second integral of the impulse response. Through analyzing the feature of the ramp response in different computed frequency ranges, it is found that the low-frequency data are essential to the shape of the underwater object while the high-frequency data are very important to the size of the object. Therefore, when employing the high-frequency data to compute the ramp response, the edge of the object can only be highlighted in the illuminated region at certain aspect. Based on this finding, a new method is developed to estimate the size of underwater objects. The present method uses different frequency ranges to determine different parameters of the underwater objects so as to achieve the best accuracy. A number of examples are presented to demonstrate the effectiveness of the present method in using the ramp response technique to identify the size of both rigid and elastic bodies.

The inverse problems in the area of the acoustic scattering often concern the determination of the size, shape, and orientation of an object using the scattered field data. This paper presents a method to retrieve the shape information of an underwater object using illuminated lengths, which can be obtained from the ramp response signatures of the object. An ellipsoidal object submerged in water is considered. Both the low and high backscattered frequency data have been employed to calculate the illuminated lengths. The calculated results show that the illuminated lengths will be more accurate, if only the high-frequency-range data are employed. For ellipsoidal objects, any three illuminated lengths that are not of a same plane can in theory fully determine the shape of the ellipsoid. As the calculated illuminated lengths contain numerical errors, the calculated results of the three semiaxes of the ellipsoid will deteriorate and become unreliable, especially when the three incident directions of the illuminated lengths become close. The reason is that the condition number of the coefficient matrix becomes big in such situations, which leads to an increase of the relative error upper limit in the calculated results. To avoid such errors in close incident wave cases, it is found that the use of more than three incident waves works very well in the shape identification of an underwater object.

Coupled vibration of arterial tubes is analyzed with the wave propagation approach and first-order shear deformation theory. Both the interior and exterior fluids are considered as compressible so that acoustic waves can be generated and propagated in the fluids. Results obtained using the theory have been evaluated against those available in the literature and the agreement has been found to be good. The theory can be used for future research on the vibration and acoustics of arterial walls. Vibration experiments were carried out on a silicone rubber tube in a water tank with a novel ultrasound stimulated optical vibrometry system. This system uses the radiation force of ultrasound to vibrate the tube at low frequency and records the resulting response by a laser vibrometer. Both the excitation and measurement are remote and noncontact. The silicone rubber tube was chosen because it has mechanical properties close to those of arteries. The fundamental frequency is well excited by the radiation force and measured with the laser. The measured fundamental frequency is in good agreement with the present theory.