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780 citation(s) found for "Dickson, Dennis W".

F1‐01‐04: DEMENTIA WITH LEWY BODIES
Lowe, Val J. , Kantarci, Kejal , Boeve, Bradley F. , Ferman, Tanis J. , Dickson, Dennis W.

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2018.06.2306 Get It

P3‐458: CLINICOPATHOLOGIC DIFFERENCES WITHIN ALZHEIMER'S DISEASE CASES FROM THE FLORIDA AUTOPSIED MULTI‐ETHNIC (FLAME) STUDY
Santos, Octavio A. , Duara, Ranjan , Lucas, John A. , Greig‐Custo, Maria T., Liesinger, Amanda M., Al‐Shaikh, Fadi S. Hanna , Ertekin‐Taner, Nilüfer , Pedraza, Otto , Graff‐Radford, Neill R. , Duara, Ranjan , Ross, Owen A. , Dickson, Dennis W. , Murray, Melissa E.

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_24 | Pages: No page available

10.1016/j.jalz.2018.06.1822 Get It

P3‐202: TDP‐43 IN ATYPICAL ALZHEIMER'S DISEASE DEMENTIA
Sahoo, Aradhana, Tosakulwong, Nirubol , Whitwell, Jennifer L. , Weigand, Stephen D. , Liesinger, Amanda M., Parisi, Joseph E., Petersen, Ronald C. , Josephs, Keith A. , Murray, Melissa E. , Senjem, Matthew L. , Machulda, Mary M. , Boeve, Bradley F. , Knopman, David S. , Dickson, Dennis W.

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2018.06.1561 Get It

P3‐129: MAPPING FUNCTIONAL REGULATORY VARIANTS AT ALZHEIMER'S DISEASE RISK LOCI
Allen, Mariet , Bredenberg, Jenny M., Reddy, Joseph S. , Sarangi, Vivekananda , Carrasquillo, Minerva M. , Lincoln, Sarah, Nguyen, Thuy , Malphrus, Kimberly G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Wang, Xue, Dickson, Dennis W.

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2018.06.1486 Get It

P1‐492: SELECTIVE VULNERABILITY OF THE CHOLINERGIC SYSTEM IN ALZHEIMER'S DISEASE SUBTYPES
Al‐Shaikh, Fadi S. Hanna , Graff‐Radford, Neill R. , Liesinger, Amanda M., Ertekin‐Taner, Nilüfer , Pedraza, Otto , Duara, Ranjan , Ferman, Tanis J. , Ross, Owen A. , Duara, Ranjan , Dickson, Dennis W. , Murray, Melissa E.

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_9 | Pages: No page available

10.1016/j.jalz.2018.06.502 Get It

P1‐160: ABI3 AND PLCG2 AS RISK FACTORS FOR ALZHEIMER'S DISEASE IN CAUCASIANS AND AFRICAN AMERICANS
Conway, Olivia J., Carrasquillo, Minerva M. , Bredenberg, Jenny M., Reddy, Joseph S. , Younkin, Curtis, Allen, Mariet , Nguyen, Thuy , Lincoln, Sarah, Malphrus, Kimberly G., Duara, Ranjan , Custo, María T. Greig, Petersen, Ronald C. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Duara, Ranjan , Dickson, Dennis W. , Graff, Caroline

Mayo Clinic

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2018.06.164 Get It

A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
Zhang, Ming , Ferrari, Raffaele, Tartaglia, Maria Carmela , Keith, Julia , Surace, Ezequiel , Wolf, Uri, Sato, Christine , Grinberg, Mark, Liang, Yan , Xi, Zhengrui, Dupont, Kyle, McGoldrick, Philip, Weichert, Anna , McKeever, Paul M. , Schneider, Raphaël , McCorkindale, Michael D, Manzoni, Claudia , Rademakers, Rosa , Graff, Caroline , Parisi, Joseph E., Petersen, Ronald C., Miller, Bruce L. , Rooij, Jeroen van , Pijnenburg, Yolande A.L. , Zee, Julie van der, Broeckhoven, Christine Van , Ber, Isabelle Le , Deerlin, Vivianna Van, Suh, EunRan , Rohrer, Jonathan D. , Mead, Simon , Öijerstedt, Linn , Pickering‐Brown, Stuart , Rollinson, Sara, Rossi, Giacomina , Tagliavini, Fabrizio , Brooks, William S. , Dobson‐Stone, Carol , Halliday, Glenda M. , Hodges, John R. , Piguet, Olivier , Binetti, Giuliano , Benussi, Luisa , Ghidoni, Roberta , Sorbi, Sandro , Bruni, Amalia C. , Galimberti, Daniela , Rainero, Innocenzo , Rubino, Elisa , Lleó, Alberto, Ruiz, Agustı́n , Hernández, Isabel, Pástor, Pau , Díez-Fairén, Mónica , Borroni, Barbara , Pasquier, Florence , Deramecourt, Vincent , Lebouvier, Thibaud , Perneczky, Robert , Diehl‐Schmid, Janine , Huey, Edward D. , Mayeux, Richard , Nalls, Michael A., Hernandez, Dena G., Singleton, Andrew B., Momeni, Parastoo, Zeng, Zhen , Hardy, John , Zinman, Lorne , Nalls, Michael A., Ramasamy, Adaikalavan , Hodges, John R. , Bartley, Lauren, Hernández, Isabel, Boada, Merçé , Padovani, Alessandro , Cairns, Nigel J. , Serpente, María , Scarpini, Elio, Blesa, Rafael , ouml, Maria Landqvist Wald, Nilsson, Karin , Mackenzie, Ian R. , Hsiung, Ging‐Yuek Robin , Attems, Johannes , Pietrini, Pietro , Baborie, Atik, Jaros, Evelyn, Tierney, Michael C, Razquín, Cristina , Ortega‐Cubero, Sara , Alonso, Elena, Alexopoulos, Panagiotis , Kurz, Alexander , Pinessi, Lorenzo , Rogaeva, Ekaterina, Giaccone, Giorgio , Rowe, James B. , Uphill, James, Collinge, John, Danek, Adrian , Deerlin, Vivianna M Van, Grossman, Murray, Trojanowski, John Q. , Leber, Isabelle, Hannequin, Didier , Golfier, Véronique, Vercelletto, Martine, Brice, Alexis , Nacmias, Benedetta, Bagnoli, Silvia , Hjermind, Lena E. , Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Fox, Nick C. , Warren, Jason D. , Spillantini, Maria Grazia , Rizzu, Patrizia , Heutink, Peter , Snowden, Julie S. , Richardson, Anna , Maletta, Raffaele , Frangipane, Francesca, Bernardi, Livia , Conidi, Maria Elena, Smirne, Nicoletta , Rademakers, Rosa, Baker, Matt , Petersen, Ronald , Knopman, David, Josephs, Keith A. , Miller, Bruce L., Karydas, Anna M., Rosen, Howard J., Scheltens, Philip , Logroscino, Giancarlo , Capozzo, Rosa , Novelli, Valeria , Franceschi, M. , Postiglione, Alfredo, Milan, Graziella , Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Rollin, Adeline, Deramecourt, Vincent, Kapogiannis, Dimitrios , Waldö, Maria Landqvist , Halliday, Glenda , Logroscino, Giancarlo , Rowe, James B , Hsiung, Gink-Yuek , Miller, Bruce L , Hardy, John , Scheltens, Philip , Rohrer, Jonathan D , Fox, Nick C , Padovani, Alessandro , Ruiz, Agustín , Pastor, Pau , Boada, Merce , Tartaglia, Maria Carmela , Pasquier, Florence , Brooks, William , McGoldrick, Philip , McCorkindale, Michael , Dickson, Dennis W. , Boeve, Bradley F. , Seeley, William W. , Swieten, John C. van , Zee, Julie van der , Deerlin, Vivianna M. Van , Nacmias, Benedetta , Scarpini, Elio , Clarimón, Jordi , Lleó, Alberto , Grafman, Jordan Henry , Robertson, Janice , Rogaeva, Ekaterina A. , Kwok, John B. , Schofield, Peter R. , Thompson, Elizabeth A. , Cruchaga, Carlos , Forloni, Gianluigi , Albani, Diego , Fenoglio, Chiara , Nilsson, Christer, Mann, David , Morris, Christopher M. , Griffiths, Timothy David , McKeith, Ian G. , Thomas, Alan , Wassermann, Eric M. , Tierney, Michael C, George‐Hyslop, Peter St , Schlachetzki, Johannes C. M. , Cappa, Stefano F. , Piaceri, Irene , Nielsen, Jørgen Erik , Riemenschneider, Markus J. , Gu, Wei , Rossor, Martin N. , Morris, Huw R. , Gerhard, Alexander , Cupidi, Chiara , Anfossi, Maria , Gallo, Maura , Dopper, Elise G.P. , Seelaar, Harro , Puca, Annibale Alessandro , Franceschi, Massimo, Chiang, Huei‐Hsin, Ferrucci, Luigi , Brice, Alexis , Rainero, Innocenzo , Galimberti, Daniela , Pijnenburg, Yolande A L , Lebouvier, Thibaud , Graff, Caroline , Borroni, Barbara

Mayo Clinic

Brain | August 31, 2018 | Volume: 141 | Issue: 10 | Pages: 2895-2907

10.1093/brain/awy238 | PMID 30252044 Get It

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
Chakrabarty, Paramita , Li, Andrew, Ladd, Thomas B., Strickland, Michael R. , Koller, Emily J., Burgess, Jeremy D. , Funk, Cory C. , Allen, Mariet , Yaroshenko, Mariya, Wang, Xue , Younkin, Curtis, Reddy, Joseph S. , Lohrer, Benjamin , Mehrke, Leonie S. , Moore, Brenda D. , Ceballos‐Diaz, Carolina, Rosario, Awilda M., Medway, Christopher, Janus, Christopher, Li, Hongdong , Giasson, Benoit I. , Price, Nathan D. , Younkin, Steven G. , Ertekin‐Taner, Nilüfer , Golde, Todd E. , Reddy, Joseph , Mehrke, Leonie, Price, Nathan D , Golde, Todd E , Cruz, Pedro E. , Wang, Xue, Liu, Xuefei , Li, Hong-Dong, Dickson, Dennis W.

Mayo Clinic

Journal of Experimental Medicine | August 29, 2018 | Volume: 215 | Issue: 9 | Pages: 2247-2264

10.1084/jem.20180484 | PMID 30158114 Get It

There is considerable interest in harnessing innate immunity to treat Alzheimer’s disease (AD). Here, we explore whether a decoy receptor strategy using the ectodomain of select TLRs has therapeutic potential in AD. AAV-mediated expression of human TLR5 ectodomain (sTLR5) alone or fused to human IgG4 Fc (sTLR5Fc) results in robust attenuation of amyloid β (Aβ) accumulation in a mouse model of Alzheimer-type Aβ pathology. sTLR5Fc binds to oligomeric and fibrillar Aβ with high affinity, forms complexes with Aβ, and blocks Aβ toxicity. Oligomeric and fibrillar Aβ modulates flagellin-mediated activation of human TLR5 but does not, by itself, activate TLR5 signaling. Genetic analysis shows that rare protein coding variants in human TLR5 may be associated with a reduced risk of AD. Further, transcriptome analysis shows altered TLR gene expression in human AD. Collectively, our data suggest that TLR5 decoy receptor–based biologics represent a novel and safe Aβ-selective class of biotherapy in AD.
APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology
Murray, Melissa E. , Soto, Alexandra I., Walton, Ronald L., Diehl, Nancy N. , Gerpen, Jay A. van, Uitti, Ryan J. , Ertekin‐Taner, Nilüfer , Petersen, Ronald C. , Graff‐Radford, Neill R. , Bu, Guojun , Ferman, Tanis J. , Ross, Owen A. , Van Gerpen, Jay A, Ross, Owen A , Bu, Guojun , Murray, Melissa E , Ferman, Tanis J , Dickson, Dennis W. , Heckman, Michael G. , Wszołek, Zbigniew K. , Knopman, David S. , Boeve, Bradley F.

Mayo Clinic

Neurology | August 24, 2018 | Volume: 91 | Issue: 12 | Pages: No page available

10.1212/wnl.0000000000006212 | PMID 30143564 Get It

Association study between multiple system atrophy and TREM2 p.R47H
Ogaki, Kotaro, Koga, Shunsuke , Martens, Yuka A. , Lorenzo‐Betancor, Oswaldo , Walton, Ronald L., Soto, Alexandra I., Vargas, Emily , Fujioka, Shinsuke , Uitti, Ryan J. , Gerpen, Jay A. van, Cheshire, William P. , Younkin, Steven G. , Low, Phillip A. , Bu, Guojun , Ross, Owen A. , Labbé, Catherine, Lorenzo-Betancor, Oswaldo, Vargas, Emily R, Van Gerpen, Jay A, Koga, Shunsuke , Cheshire, William P , Ross, Owen A , Bu, Guojun , Heckman, Michael G. , Labbé, Catherine , Wszołek, Zbigniew K. , Singer, Wolfgang , Dickson, Dennis W.

Mayo Clinic

Neurology Genetics | August 2, 2018 | Volume: 4 | Issue: 4 | Pages: No page available

10.1212/nxg.0000000000000257 | PMID 30109269 Get It