Citations

SUMMARY Quantification and characterization of the hemodynamic environment created after flow diversion treatment of cerebral aneurysms is important to understand the effects of flow diverters and their interactions with the biology of the aneurysm wall and the thrombosis process that takes place subsequently. This paper describes the construction of multi‐modality image‐based subject‐specific CFD models of experimentally created aneurysms in rabbits and subsequently treated with flow diverters. Briefly, anatomical models were constructed from 3D rotational angiography images, flow conditions were derived from Doppler ultrasound measurements, stent models were created and virtually deployed, and the results were compared with in vivo digital subtraction angiography and Doppler ultrasound images. The models were capable of reproducing in vivo observations, including velocity waveforms measured in the parent artery, peak velocity values measured in the aneurysm, and flow structures observed with digital subtraction angiography before and after deployment of flow diverters. The results indicate that regions of aneurysm occlusion after flow diversion coincide with slow and smooth flow patterns, whereas regions still permeable at the time of animal sacrifice were observed in parts of the aneurysm exposed to larger flow activity, that is, higher velocities, more swirling, and more complex flow structures. Copyright © 2014 John Wiley & Sons, Ltd.

Flow diversion treatment of cerebral aneurysms has increasingly been considered, especially for large complex aneurysms with wide necks that are difficult to treat with coils of by clipping. However, the relationship between the hemodynamic environment created immediately after implantation of flow diverters (FD) and the subsequent aneurysm occlusion is poorly understood [1].

Since treatment of cerebral aneurysms with flow diverters (FD) has gained much attention in recent years, it is important to understand what is the effect of these devices on the flow through arteries jailed or crossed by these devices [1].