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21 citation(s) found for "Grigoriou, Emmanouil".

Post-traumatic Triradiate Cartilage Physeal Bar Excision with 3D Navigation
Varas‐Rodríguez, Emil , Yuan, Brandon J. , Milbrandt, Todd A. , Grigoriou, Emmanouil , Yuan, Brandon

Mayo Clinic

JBJS Case Connector | July 24, 2025 | Volume: 15 | Issue: 3 | Pages: No page available

10.2106/jbjs.cc.25.00177 | PMID 40705856 Get It

Case: An 8-year-old boy underwent open reduction and internal fixation for pelvic and femoral fractures following a crush injury. At nine months postoperatively, computed tomography demonstrated a triradiate physeal bar contralateral to operated hemipelvis. A navigated physeal bar excision with O-arm navigation and low-dose radiation protocol was performed. Conclusion: Triradiate bar excision presents a technically challenging procedure that may be offset by O-arm navigation utilization, which provides accurate, real-time imaging that facilitates complete physeal bar excision while mitigating risk of damage to surrounding structures. Our low-dose protocol yielded a total exposure of 0.914 mSv, comparable with 1.5 pelvic radiographs.
Three-dimensional biomechanical analysis of flexible intramedullary nailing constructs in length-unstable pediatric femur fractures
Grigoriou, Emmanouil , Transtrum, M. Bryant , Deshpande, Ameya H., Doak, Jeremy P., Ehrensberger, Mark T. , Varas-rodriguez, Emil, Varas‐Rodríguez, Emil , Deshpande, Ameya H.

Mayo Clinic

Journal of Pediatric Orthopaedics B | June 18, 2025 | Volume: 34 | Issue: 6 | Pages: 579-587

10.1097/bpb.0000000000001267 | PMID 40530531 Get It

Flexible intramedullary nail fixation of pediatric femoral shaft fractures offers advantages such as shorter hospital stays, faster return to function, and less associated costs when compared with traction and casting. This study compared the biomechanical performance of three configurations: 2CS, 2CL, and 3CL. Thirty synthetic femur models with identical, length-unstable, spiral fractures were tested using a three-dimensional camera system to assess real-time micromotion. Three groups were analyzed: (a) 2CS – two 3.5 mm C- and S-shaped nails inserted anterograde, (b) 2CL – one ‘C’ and one ‘S’ shaped 3.5 mm titanium nail-inserted retrograde from a single lateral entry, (c) 3CL – two ‘C’ shaped 3.5 mm titanium nails inserted medially and laterally with a third ‘C’ shaped 2.5 mm nail placed retrograde from an anterolateral site. Torsional loading, cyclical loading, and load-to-failure tests were conducted. The 3CL configuration demonstrated superior biomechanical performance. It exhibited the highest torsional stiffness [0.67 ± 0.06 Nm/° for external rotation (ER), 0.404 = ± 0.06 Nm/° for internal rotation (IR); P = 0.002], least displacement (0.05 ± 0.02 vs. 0.30 ± 0.02 mm for 2CL and 0.57 ± 0.05 mm for 2CS; P = 0.012), and required the highest load-to-failure (162 ± 83 vs. 1064 ± 75 N for 2CL and 790 ± 34 N for 2CS; P = 0.016).The 3CL configuration provided superior strength and stability across all tests, supporting its role in the fixation of length-unstable pediatric femoral fractures.
Periacetabular Osteotomy Often Results in Inpatient Stay: A Tertiary Referral Institution’s Experience Supporting This Common Postoperative Course
Meta, Fabien , Clark, Sean C. , Gomez-Ruiz, Karen, Trousdale, Robert T. , Grigoriou, Emmanouil , Hevesi, Mario , Hevesi, Mario , Sierra, Rafael J.

Mayo Clinic

Orthopaedic Journal of Sports Medicine | May 29, 2025 | Volume: 13 | Issue: 5 | Pages: No page available

10.1177/23259671251341913 | PMID 40453958 Get It

Background: Periacetabular osteotomy (PAO) is a complex procedure historically requiring inpatient stay. However, there is increased emphasis for other complex orthopaedic procedures (eg, arthroplasty) to be performed on an outpatient basis by insurance companies. Increasing resistance to insurance approval of inpatient listing for PAO patients at the participating institution suggests that this changing tide is affecting PAO surgery. Purpose: To (1) investigate the proportion of PAOs various surgical listing classifications (outpatient, outpatient-overnight, inpatient, etc), (2) determine the incidence of subsequent denial/request for additional documentation for approval of inpatient stay after PAO, and (3) characterize the accuracy of preoperative patient listing classification as well as mean length of stay (LOS) and incidence of successful same-day discharge after PAO at a single institution. Study Design: Case series; Level of evidence, 3. Methods: A retrospective chart review was performed to identify all PAOs, performed by 4 participating surgeons, at a single academic institution over a 2-year period. The initial listing status as an outpatient-overnight or inpatient procedure was identified. Whether a preoperative peer review was required for approval of inpatient listings as well as if additional documentation was necessary to convert outpatient-overnight listings to inpatient stays were also recorded. Results: A total of 140 PAOs among 117 patients were performed with 25 (17.9%) initially listed as an inpatient stay and 115 (82.1%) listed as outpatient-overnight. Of the 25 PAOs listed as inpatient, 2 (8.0%) required a preoperative peer review process to justify or clarify listing status. The mean LOS was 1.9 ± 1.4 days with 55.7% (78/140) of PAOs staying ≥2 nights in the hospital. Only 6 PAOs (4.3%) went home the same day as surgery. Patients who underwent PAO with concomitant hip arthroscopy stayed on average 2.4 ± 1.2 days in comparison with 1.6 ± 1.4 days for those who underwent PAO alone ( P < .001). Of the 115 PAOs listed as an outpatient-overnight, 53 (46.1%) converted to an inpatient stay, all of which required service documentation to support conversion to inpatient status. Conclusion: Over half of PAOs performed resulted in an inpatient stay with patients spending ≥2 nights in the hospital. Additionally, all conversions from outpatient-overnight to inpatient required additional service documentation to support status conversion. Understanding trends in postoperative hospitalizations and LOS may allow for better informed partnerships between surgeons and insurance companies creating more efficient preauthorizations, billing practices, and expected patterns of patient care and discharge.
EP6.38 Outpatient Periacetabular Osteotomy: Common Clinical Fact or Insurance Fiction?
Meta, Fabien , Iyer, Sanathan, Ward, Gavin, Gomez-Ruiz, Karen, Trousdale, Robert T. , Grigoriou, Emmanouil , Clark, Sean C. , Kang, Louis , Iyer, Sanathan, Ward, Gavin, Sierra, Rafael J. , Hevesi, Mario

Mayo Clinic

Journal of Hip Preservation Surgery | March 31, 2025 | Volume: 12 | Issue: Supplement_1 | Pages: i101-i102

10.1093/jhps/hnaf011.327 Get It

Abstract Introduction: Periacetabular osteotomy (PAO) is a complex procedure historically requiring inpatient stay. There is increased emphasis for these to be performed on an outpatient basis by insurance companies. The purpose of this study was to investigate the proportion of various surgical listing classifications (outpatient, outpatient-overnight, inpatient), the incidence of subsequent denial/request for additional documentation for approval of inpatient stay, and to characterize the average length of stay (LOS) following PAO. Methods: A retrospective chart review was performed to identify all PAOs, performed by four participating surgeons, at a single academic institution over a two-year period. The initial listing status as an outpatient-overnight or inpatient procedure was identified. Whether a preoperative peer review was required for approval of inpatient listings as well as if additional documentation was necessary to convert outpatient-overnight listings to inpatient stays were also recorded. Results: A total of 140 PAOs amongst 117 patients were performed with 25 (17.9%) initially listed as an inpatient stay and 115 (82.1%) listed as outpatient-overnight. Of the 25 PAOs listed as inpatient, 2 (8.0%) required a preoperative peer review process to justify or clarify listing status. The average LOS was 1.9 ± 1.4 days with 55.7% (78/140) of PAOs staying two or more nights in the hospital. Only 6 PAOs (4.3%) went home the same day as surgery. Of the 115 PAOs listed as an outpatient-overnight, 53 (46.1%) converted to an inpatient stay. Conclusion: Over half of PAOs performed required inpatient stay beyond outpatient-overnight status. Preoperative peer-to-peer review for inpatient stay approval was modestly frequent (8% of inpatient listings), and all conversions to inpatient required additional service documentation to support status conversion. Understanding trends in postoperative hospitalizations and LOS might allow for better informed partnerships between surgeons and insurance companies creating more efficient pre-authorizations, billing practices, and expected patterns of patient care and discharge.
Characterizing hip joint morphology using a multitask deep learning model
Khosravi, Bardia , Bukowiec, Lainey G , Oeding, Jacob F. , Rouzrokh, Pouria, Grigoriou, Emmanouil , Wyles, Cody C. , Mickley, John P. , Oeding, Jacob F , Wyles, Cody C , Khosravi, Bardia , Erickson, Bradley J. , Sierra, Rafael J. , Taunton, Michael J.

Mayo Clinic

Journal of Hip Preservation Surgery | December 12, 2024 | Volume: 12 | Issue: 1 | Pages: 27-32

10.1093/jhps/hnae041 | PMID 40331073 Get It

Abstract Deep learning is revolutionizing medical imaging analysis by enabling the classification of various pathoanatomical conditions at scale. Unfortunately, there have been a limited number of accurate and efficient machine learning (ML) algorithms that have been developed for the diagnostic workup of morphological hip pathologies, including developmental dysplasia of the hip and femoroacetabular impingement. The current study reports on the performance of a novel ML model with YOLOv5 and ConvNeXt-Tiny architecture in predicting the morphological features of these conditions, including cam deformity, ischial spine sign, dysplastic appearance, and other abnormalities. The model achieved 78.0% accuracy for detecting cam deformity, 87.2% for ischial spine sign, 76.6% for dysplasia, and 71.6% for all abnormalities combined. The model achieved an Area under the Receiver Operating Curve of 0.89 for ischial spine sign, 0.80 for cam deformity, 0.80 for dysplasia, and 0.81 for all abnormalities combined. Inter-rater agreement among surgeons, assessed using Gwet’s AC1, was substantial for dysplasia (0.83) and all abnormalities (0.88), and moderate for ischial spine sign (0.75) and cam deformity (0.61).
Tibiopelvic Rotational Arthroplasty for Pediatric Gorham-Stout Disease
Grigoriou, Emmanouil , Transtrum, M. Bryant , Oishi, Scott N. , Johnston, Charles E. , Johnson, Megan , Oishi, Scott , Johnson, Megan E

Mayo Clinic

JBJS Case Connector | December 5, 2024 | Volume: 14 | Issue: 4 | Pages: No page available

10.2106/jbjs.cc.24.00172 | PMID 39637061 Get It

Case: This is a case of a 6-year-old patient diagnosed with Gorham-Stout disease (GSD), a rare lymphangiogenic skeletal disorder, localized to the left femur. Initial nonoperative treatment with pharmaceuticals and bracing was unsuccessful. We describe a definitive operative treatment with radical femoral resection and a modified rotationplasty technique through a tibiopelvic rotational hip arthroplasty. At 2-year follow-up, the patient was able to walk with a prosthetic device. Conclusion: The use of this modified rotationplasty technique is an effective treatment option for patients with femoral GSD to improve function and quality of life.
Incidence and Long-term Follow-up of Pediatric Lateral Condyle Fractures: A Population-based Study
Wellings, Elizabeth P. , Sullivan, Mikaela H. , Thapa, Prabin , Grigoriou, Emmanouil , Stans, Anthony A. , Shaughnessy, William J. , Milbrandt, Todd A. , Larson, A. Noelle

Mayo Clinic

Journal of Pediatric Orthopaedics | November 22, 2024 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1097/bpo.0000000000002825 | PMID 39575594 Get It

Objective: Lateral condyle fractures are the second most common pediatric elbow fracture after supracondylar humeral fractures. Early complications are frequent which can lead to development of long-term problems. Current literature has evaluated short-term outcomes, but few studies have investigated long-term outcomes into adulthood. Our hypothesis is that the majority of pediatric patients with a lateral condyle fracture will have minimal complications and few surgeries as they age. Methods: A population-based database was used to identify patients who sustained a lateral condyle fracture before the age of 18 between 1966 and 2012. Electronic medical records from all treatment centers in the county were reviewed for clinical and radiographic data. Analysis was performed to determine incidence and long term outcomes based on fracture type and treatment. Results: From 1966 to 2012, 227 pediatric lateral condyle fractures were identified. One hundred seventy-seven fractures (78%) had at least 10 year clinical follow up. Incidence was found to be 13.97 per 100,000. We identified 80 (45%) Weiss type 1, 61 (34%) type 2, and 37 (21%) type 3 fractures. The overall complication rate was 17%, of which 47% were identified >10 years from injury. There was no significant difference in complication rates based on fracture type (P = 0.18) or treatment type (P = 0.55). The most common complication was malunion (n = 15), followed by fishtail deformity (n = 4), stiffness (n = 3), lateral epicondylitis (n = 3), nonunion (n = 2), osteoarthritis (n = 2), and tardy ulnar nerve palsy (n = 1). Five patients underwent revision surgery for nonunion, cubitus valgus, malunion with loose bodies, capitellar osteochondral dessicans with malalignment, and ulnar nerve palsy. Conclusions: This population-based study estimated the overall incidence of pediatric lateral condyle fractures to be 14 per 100,000. Displaced fractures had a higher incidence than undisplaced fractures. Complications beyond 10 years are rare, but the need for future revision surgery is possible, therefore, proper patient and family education is necessary at the time of injury. This is the largest study with the longest follow-up for pediatric lateral condyle fractures. Complications were rare but resulted in a 17% complication rate and a 3% reoperation rate at a minimum. Level of Evidence: Level III.
Osteochondral Allograft Transplantation for the Treatment of an Acetabular Defect
Clark, Sean C. , Pan, Xuankang , Grigoriou, Emmanouil , Krych, Aaron J. , Hevesi, Mario , Sierra, Rafael J. , Krych, Aaron J , Sierra, Rafael J , Hevesi, Mario

Mayo Clinic

JBJS Case Connector | May 31, 2024 | Volume: 14 | Issue: 2 | Pages: No page available

10.2106/jbjs.cc.24.00033 | PMID 38820204 Get It

Case: A 20-year-old woman presented with a unipolar, 1.8 × 1.8-cm osteochondral defect of the left acetabulum. Osteochondral allograft transplantation was performed using a medial tibial plateau allograft resulting in excellent clinical outcomes across 4 different outcome scores and maintenance of the joint space at 4.3 years postoperatively. Conclusion: Although previous literature has demonstrated long-term clinical success of osteochondral allograft transplantation in knee, excellent clinical outcomes can also be obtained in the hip. Thus, osteochondral allograft transplantation may be a viable treatment option for adolescents and young adults with concomitant cartilage and subchondral bone hip defects.
What Is the Relevance of Post-Reduction MRI Today and Where Do We Go from Here?
Grigoriou, Emmanouil , Shaughnessy, William J.

Mayo Clinic

Journal of Bone and Joint Surgery | January 17, 2024 | Volume: 106 | Issue: 2 | Pages: e3

10.2106/jbjs.23.01233 | PMID 38231196 Get It

Long-Term Outcomes at Skeletal Maturity of Combined Pelvic and Femoral Osteotomy for the Treatment of Legg–Calve–Perthes Disease
Regan, Christina , Su, Alvin W.Y. , Stans, Anthony A. , Milbrandt, Todd A. , Shaughnessy, William J. , Grigoriou, Emmanouil , Regan, Christina M, Larson, A. Noelle

Mayo Clinic

Journal of Clinical Medicine | September 1, 2023 | Volume: 12 | Issue: 17 | Pages: 5718

10.3390/jcm12175718 | PMID 37685785 Get It

Surgical treatment for Legg–Calve–Perthes disease (LCPD) is recommended for older children with moderate to severe disease. We sought to determine whether double osteotomies lead to improved radiologic outcomes compared to reported non-operative outcomes. Patients older than 6 years of age diagnosed with LCPD lateral pillar B or C who were treated with pelvic and femoral osteotomies were included. Radiologic outcomes and leg-length discrepancies were assessed using the Stulberg classification and were compared with the current literature. Fifteen hips in fourteen patients were treated with double osteotomy for LCPD, and seven had lateral pillar C disease (47%). The mean age at surgery was 8.6 years (range, 7.2–10.4) and the mean age at follow-up was 20.2 years (range, 14.2–35.6). At a mean 11.6-year follow-up (range: 6.3–25.2), double osteotomy resulted in 40% of patients having Stulberg I/II scores, 27% having Stulberg III scores, and 33% having Stulberg IV/V scores. The mean leg-length discrepancy was 1.4 cm in lateral pillar C patients compared to 0.8 cm in lateral pillar B patients. Four patients underwent additional surgeries, including two who required total hip arthroplasty. Double osteotomy as an alternative surgical procedure for the treatment of LCPD did not show improved outcomes when compared to historic non-operative cohorts.