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Eyo, Ukpong B.

https://orcid.org/0000-0002-1294-475X

A5017015858 | I51556381

Mayo Clinic

University of Virginia

Citations 11

Microglial interactions with the neurovascular system in physiology and pathology

Developmental Neurobiology | January 10, 2018 | Volume: 78 | Issue: 6 | Pages: 604-617

10.1002/dneu.22576 | PMID 29318762

ABSTRACT Microglia as immune cells of the central nervous system (CNS) play significant roles not only in pathology but also in physiology, such as shaping of the CNS during development and its proper maintenance in maturity. Emerging research is showing a close association between microglia and the neurovasculature that is critical for brain energy supply. In this review, we summarize the current literature on microglial interaction with the vascular system in the normal and diseased brain. First, we highlight data that indicate interesting potential involvement of microglia in developmental angiogenesis. Then we discuss the evidence for microglial participation with the vasculature in neuropathologies from brain tumors to acute injuries such as ischemic stroke to chronic neurodegenerative conditions. We conclude by suggesting future areas of research to advance the field in light of current technical progress and outstanding questions. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 604–617, 2018
Faculty Opinions recommendation of Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 26, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718384688.793501754

Faculty Opinions recommendation of TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | October 22, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718535226.793500862

Faculty Opinions recommendation of Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | July 7, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718262127.793496765

Faculty Opinions recommendation of Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | July 7, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718355425.793496775

Faculty Opinions recommendation of Transcranial amelioration of inflammation and cell death after brain injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | May 12, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718201301.793494630

Faculty Opinions recommendation of Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | February 24, 2014 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718215513.793491233

Faculty Opinions recommendation of Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | December 31, 2013 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718018771.793488375

Faculty Opinions recommendation of TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | December 31, 2013 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.718155710.793488896

Faculty Opinions recommendation of Layer V cortical neurons require microglial support for survival during postnatal development.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature | November 29, 2013 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.3410/f.717991727.793487267