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Pabelick, C.M.

A5021712531 | I1330342723

Mayo Clinic

Mayo Clinic

Citations 40

Receptor Specific Estrogen Signaling Regulates Extracellular Matrix Deposition in Human Airway Smooth Muscle Remodeling

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2189-A2189

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2189

Hyperoxia-Induced Soluble Guanylyl Cyclase (sGC) Dysfunction in Developing Airway Involves the Calcium Sensing Receptor (CaSR)

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2180-A2180

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2180

Proteostasis and Senescence in the Aging Lung

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2178-A2178

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2178

Kisspeptins Expression and Function in Asthmatic Human Airway Smooth Muscle

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2174-A2174

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2174

Calcium-Sensing Receptor Contributes to Hyperoxia-Induced Enhancement of Calcium Regulation and Remodeling in Human Fetal Airway Smooth Muscle

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2169-A2169

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2169

Effect of Stretch on Hyaluronan Expression and Signaling in Developing Human Airway Smooth Muscle

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2162-A2162

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2162

Thymic Stromal Lymphopoietin Role in Human Pulmonary Artery Smooth Muscle Proliferation and Contractility

C71. PULMONARY HYPERTENSION | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5498-A5498

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5498

Moderate Hyperoxia Induces Senescence in Human Fetal Lung Fibroblasts

C70. NEONATAL AND PEDIATRIC LUNG DISEASE | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5494-A5494

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5494

Dexamethasone Reduces Effects of Brain-Derived Neurotrophic Factor on Human Airway Smooth Muscle

C19. NEW PATHWAYS REGULATING AIRWAY SMOOTH MUSCLE CONTRACTION: POTENTIAL TARGETS FOR ASTHMA THERAPY | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A4286-A4286

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4286

Muscarinic receptor stimulation modulates the effect of halothane on Mn2+ influx in airway smooth muscle

American Journal of Physiology-Cell Physiology | December 24, 2017 | Volume: 273 | Issue: 3 | Pages: C868-C873

10.1152/ajpcell.1997.273.3.c868 | PMID 9316407

Prior studies suggest that the mechanism of action by which halothane relaxes airway smooth muscle depends on the contractile state of the cell. We hypothesized that halothane would inhibit the influx of Ca2+ into canine airway smooth muscle cells during submaximal, but not maximal, muscarinic stimulation. This hypothesis was tested by using the rate of quenching of fura 2 fluorescence by Mn2+ in strips of canine tracheal smooth muscle as an index of Ca2+ influx. Acetylcholine (ACh) produced a dose-dependent increase in Mn2+ influx. Halothane (0.64 +/- 0.05 microM) significantly decreased Mn2+ influx and intracellular Ca2+ concentration when added to strips stimulated with a submaximal concentration of ACh (0.3 microM) but had no effect on Mn2+ influx or intracellular Ca2+ concentration during maximal stimulation with ACh (100 microM). Similar results were observed when the strips were treated with verapamil. These results demonstrate that anesthetic effects on Ca2+ homeostasis in intact canine tracheal smooth muscle cells may be critically modulated by receptor-linked mechanisms.