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Kuehl, Tobias

A5064746529 | I136199984

Mayo Clinic

Harvard University

Citations 1

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Science Translational Medicine | December 13, 2017 | Volume: 9 | Issue: 420 | Pages: No page available

10.1126/scitranslmed.aal3765 | PMID 29237758

ABT-263 blocks BCL-X L to induce apoptosis in human dermal fibroblasts from patients with scleroderma and in myofibroblasts in mice, reversing dermal fibrosis.