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Boustani, Malaz

A5046402446 | I4394709130

Mayo Clinic

Indiana University School of Medicine

Citations 2

A Pilot Randomized Controlled Clinical Trial to Test the Feasibility, Acceptability, and Usability of iPREPARED; A Mobile Health Technology for Patients and Care Partners

Delirium | June 16, 2025 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.56392/001c.127872 | PMID 40919583

Background Family participation in the delivery of nonpharmacological measures has shown in past studies to prevent 17-75% of incident delirium. A scalable and sustainable method to partner with family (i.e., care partners) and support their delivery of nonpharmacologic measures is needed. Objectives To test the feasibility, acceptability, and usability of iPREPARED in a pilot randomized controlled clinical trial (RCT). iPREPARED is a mobile health technology co-designed with patients and care partners containing resources on nonpharmacological interventions to prevent delirium. Methods Hospitalized adults ( > 65 years) with > 1 delirium risk factor and a care partner (family or friend > 18yo) willing to participate were enrolled. The primary outcomes were feasibility, acceptability, and usability. Descriptive statistics are reported. Results In total, 23 dyads completed the study (median age 72 years (IQR 64, 79), 60% male, and 100% Caucasian). Dyads reported that iPREPARED was acceptable, with moderate usability. Recruitment in the emergency department was feasible whereas recruitment once hospitalized and admitted was more difficult. Conclusion The study design was feasible. iPREPARED was acceptable and usable as an intervention.
Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults

JAMA Neurology | April 18, 2016 | Volume: 73 | Issue: 6 | Pages: 721

10.1001/jamaneurol.2016.0580 | PMID 27088965