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DeTure, Michael

https://orcid.org/0000-0002-4363-1262

A5025029869 | I1330342723

Mayo Clinic

Mayo Clinic

Citations 65

O2‐05‐04: The involvement of the 5lipoxygenase pathway in tauopathy

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_4 | Pages: No page available

10.1016/j.jalz.2015.07.157

P3‐004: TDP‐43 FILAMENT ASSEMBLY IS INHIBITED BY HEAT SHOCK PROTEINS

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1091

P1‐372: Regulation of the Hsp90 chaperone complex by HDAC6

Alzheimer's & Dementia | July 11, 2010 | Volume: 6 | Issue: 4S_Part_9 | Pages: No page available

10.1016/j.jalz.2010.05.926

P1‐371: Characteristics of cytosolic hyperphosphorylated tau species in rTg4510 mouse brain

Alzheimer's & Dementia | July 11, 2010 | Volume: 6 | Issue: 4S_Part_9 | Pages: No page available

10.1016/j.jalz.2010.05.925

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Science | July 14, 2005 | Volume: 309 | Issue: 5733 | Pages: 476-481

10.1126/science.1113694 | PMID 16020737

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.