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Khanna, Maya

Mayo Clinic

Children's Hospital of Philadelphia

Citations 1

Assessing Mucosal Recovery During the First 15 Months of Adopting a Gluten-Free Diet in Children With Celiac Disease

American Journal of Gastroenterology | March 14, 2025 | Volume: 120 | Issue: 7 | Pages: 1657-1661

10.14309/ajg.0000000000003400 | PMID 40084739

INTRODUCTION: Determine contemporary rates of early mucosal recovery in children with celiac disease (CeD). METHODS: Multicenter retrospective cohort study in Canada and the United States. Children diagnosed with CeD between 2016 and 2021 who underwent a follow-up biopsy within 15 months of diagnosis were included. RESULTS: Overall, 96 of 130 children (74%) had mucosal recovery, including 48% children (12/25) who were assessed within 3 months. Musculoskeletal symptoms at diagnosis were the only clinical characteristic associated with persistent enteropathy. DISCUSSION: While mucosal recovery can occur within months, more than a quarter of children with CeD had persistent enteropathy within 15 months of treatment.