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Cico, Alba

A5041728357 | I110736937

Mayo Clinic

Délégation Paris 5

Citations 1

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1

Blood | November 2, 2013 | Volume: 123 | Issue: 4 | Pages: 509-519

10.1182/blood-2013-07-515874 | PMID 24184684

Key Points TPO specifically activates Erk and NF-κB pathways in hematopoietic stem and progenitor cells. Erk and NF-κB cooperate to trigger their common target, Iex-1, and DNA-PK-dependent NHEJ activation in HSPCs upon irradiation.