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Stewart, Robert A.

Mayo Clinic

Mayo Clinic in Arizona

Citations 1

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Blood | July 25, 2016 | Volume: 128 | Issue: 9 | Pages: 1226-1233

10.1182/blood-2016-02-698092 | PMID 27458004

Key Points The incidence of mutations within the MAPK pathway, the CRBN pathway, and TP53 is significantly increased in drug-refractory MM. Mutations in CRBN might contribute to IMiD resistance in drug-refractory MM.