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Law, Mark E.

Mayo Clinic

Mayo Clinic in Arizona

Citations 1

The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma

Blood | April 2, 2015 | Volume: 125 | Issue: 20 | Pages: 3118-3127

10.1182/blood-2014-05-578575 | PMID 25833963

Key PointsThe NF-κB subunits p52 and RelB increase IRF4 promoter activity and expression in PTCL cells. A positive feedback loop involving CD30, NF-κB, and IRF4 drives PTCL cell proliferation and can be blocked by NF-κB inhibitors.