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Lee, Amani

0000-0003-2687-3582

Mayo Clinic

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States.

Citations 3

Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling

American Journal of Physiology-Gastrointestinal and Liver Physiology | August 22, 2026 | Volume: 331 | Issue: 4 | Pages: G399-G413

10.1152/ajpgi.00223.2026 | PMID 42631413

This study presents a refined murine MetALD model designed to distinguish ethanol-modified features from FFC-driven metabolic steatohepatitis. Chronic ethanol did not uniformly worsen liver injury. Instead, it selectively modified disease trajectory through greater early collagen-positive fibrotic remodeling, altering lipid-droplet architecture, and context-dependent inflammatory chemokine signaling. By 24 wk, FFC and FFC/ethanol injury programs converged, supporting MetALD as a timing- and pathway-dependent modification of metabolic steatohepatitis.
Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease

Journal of Medicinal Chemistry | April 14, 2025 | Volume: 68 | Issue: 8 | Pages: 8091-8105

10.1021/acs.jmedchem.4c02555 | PMID 40227166

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes

Journal of Medicinal Chemistry | January 10, 2022 | Volume: 65 | Issue: 3 | Pages: 2342-2360

10.1021/acs.jmedchem.1c01779 | PMID 35007061