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Grahn, Peter J

0000-0002-2976-814X

Mayo Clinic

Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, United States.

Citations 2

Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury

Journal of Neurophysiology | April 11, 2026 | Volume: 135 | Issue: 5 | Pages: 1220-1230

10.1152/jn.00438.2025 | PMID 41963069

Epidural and dorsal root stimulation have emerged as promising therapies to restore function after spinal cord injury. However, how each modality uniquely or jointly engages spinal circuits remains unclear. To address this, we analyzed leg electromyography (EMG) responses to epidural stimulation (ES) and dorsal root ganglia stimulation (DRGS) delivered to the lumbosacral cord in the same individuals.
Prevalence of autonomic dysreflexia during spinal cord stimulation after spinal cord injury

Journal of Neurophysiology | September 25, 2024 | Volume: 132 | Issue: 5 | Pages: 1371-1375

10.1152/jn.00343.2024 | PMID 39442001

Spinal cord stimulation for motor recovery after spinal cord injury is a popular research intervention, though off-target effects are a concern. Using continual blood pressure and heart rate recordings during passive spinal cord stimulation parameter testing, we identified frequent episodes of autonomic dysreflexia that were rarely associated with symptoms. This presents a previously unrecognized risk of spinal cord stimulation and appropriate vigilance in targeted monitoring is urged to maintain participant safety.