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Brendel, Matthew

0000-0003-3417-4597

Mayo Clinic

Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA.

Citations 1

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Science Translational Medicine | December 1, 2021 | Volume: 13 | Issue: 622 | Pages: No page available

10.1126/scitranslmed.abe3947 | PMID 34851693

R47H- TREM2 mutation enhances AKT signaling in human AD microglia and mediates proinflammatory and synaptic toxicity in a tauopathy mouse model.