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Schouteden, Sarah

A5076934149 | I99464096

Mayo Clinic

KU Leuven

Citations 1

A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression

Blood | December 14, 2012 | Volume: 121 | Issue: 5 | Pages: 781-790

10.1182/blood-2012-07-446443 | PMID 23243277

Key PointsCytokine-induced loss of murine as well as human HSPC homing during ex vivo culture can be prevented by addition of BMP4. In HSPCs, BMP4 directly regulates Integrin-α4 expression through SMAD-independent p38 MAPK-mediated signaling.