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Schembri Wismayer, Daniel

Mayo Clinic

Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota.

Citations 3

Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes

American Journal of Physiology-Endocrinology and Metabolism | June 7, 2023 | Volume: 325 | Issue: 2 | Pages: E119-E131

10.1152/ajpendo.00043.2023 | PMID 37285600

This experiment studied the effect of changes in overnight concentrations of free fatty acids (FFAs) and glucose on β-cell function and glucose metabolism. In response to elevation of these metabolites, the dynamic component of the β-cell response to glucose was impaired. This suggests that in health overnight hyperglycemia and FFA elevation can deplete preformed insulin granules in the β-cell.
The Effect of Diabetes-Associated Variation in TCF7L2 on Postprandial Glucose Metabolism When Glucagon and Insulin Concentrations Are Matched

Metabolic Syndrome and Related Disorders | April 20, 2022 | Volume: 20 | Issue: 6 | Pages: 329-335

10.1089/met.2021.0136 | PMID 35442800

Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects

American Journal of Physiology-Endocrinology and Metabolism | October 18, 2021 | Volume: 321 | Issue: 5 | Pages: E728-E736

10.1152/ajpendo.00284.2021 | PMID 34658253

In prediabetes, anthropometric characteristics as well as insulin action do not alter the hepatic response to glucagon. The postprandial suppression or lack of suppression of glucagon secretion is an important factor governing postprandial glucose tolerance independent of insulin secretion.