Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Citations 1
Oncolytic Foamy Virus: Generation and Properties of a Nonpathogenic Replicating Retroviral Vector System That Targets Chronically Proliferating Cancer Cells
Journal of Virology | March 10, 2021 | Volume: 95 | Issue: 10 | Pages: No page available
The infectivity of certain retroviruses is limited to dividing cells, which makes them attractive tools for targeting cancer cell proliferation. Previously developed replication-competent gammaretroviral vectors spread efficiently in rapidly dividing cancer cells, but not in cancer cells that divide more slowly.