The Public Health Research Institute at the International Center for Public Health, New Jersey Medical School-Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Citations 1
Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis
Antimicrobial Agents and Chemotherapy | February 17, 2020 | Volume: 64 | Issue: 5 | Pages: No page available
This study was conducted in treatment-naive adults with drug-susceptible pulmonary tuberculosis in Port-au-Prince, Haiti, to assess the safety, bactericidal activity, and pharmacokinetics of nitazoxanide (NTZ). This was a prospective phase II clinical trial in 30 adults with pulmonary tuberculosis. Twenty participants received 1 g of NTZ orally twice daily for 14 days. A control group of 10 participants received standard therapy over 14 days. The primary outcome was the change in time to culture positivity (TTP) in an automated liquid culture system.