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Jaffe, Elaine S

0000-0003-4632-0301

Mayo Clinic

National Institutes of Health, National Cancer Institute, Bethesda, MD.

Citations 12

A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

Blood | May 16, 2018 | Volume: 132 | Issue: 4 | Pages: 413-422

10.1182/blood-2018-03-838136 | PMID 29769262

Key PointsA new molecular assay identifies conventional and leukemic nonnodal MCL with differing clinicobiological features. The integration of the novel assay with genetic alterations identifies subsets of MCL patients with different management and outcome.
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

Blood | June 3, 2014 | Volume: 124 | Issue: 9 | Pages: 1473-1480

10.1182/blood-2014-04-571091 | PMID 24894770

Key Points ALK-negative ALCLs have chromosomal rearrangements of DUSP22 or TP63 in 30% and 8% of cases, respectively. DUSP22-rearranged cases have favorable outcomes similar to ALK-positive ALCLs, whereas other genetic subtypes have inferior outcomes.